Limitations of functional neuroimaging for patient selection and surgical planning in glioma surgery

Abstract

The optimal surgical management of gliomas requires a balance between surgical cytoreduction and preservation of neurological function. Preoperative functional neuroimaging, such as functional MRI (fMRI) and diffusion tensor imaging (DTI), has emerged as a possible tool to inform patient selection and surgical planning. However, evidence that preoperative fMRI or DTI improves extent of resection, limits neurological morbidity, and broadens surgical indications in classically eloquent areas is lacking. In this review, the authors describe facets of functional neuroimaging techniques that may limit their impact on neurosurgical oncology and critically evaluate the evidence supporting fMRI and DTI for patient selection and operative planning in glioma surgery. The authors also propose alternative applications for functional neuroimaging in the care of glioma patients.

Keywords: BOLD = blood oxygen level–dependent; CBV = cerebral blood volume; DES = direct electrical stimulation; DTI = diffusion tensor imaging; diffusion tensor imaging; direct electrical stimulation; fMRI = functional MRI; functional MRI; rs-fMRI = resting-state fMRI; tractography.