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Review
. 2020 Mar;130 Suppl 1(Suppl 1):109835.
doi: 10.1016/j.ijporl.2019.109835. Epub 2019 Dec 24.

Panel 3: Genomics, precision medicine and targeted therapies

Regie Lyn P Santos-Cortez  1 , Mahmood F Bhutta  2 , Joshua P Earl  3 , Lena Hafrén  4 , Michael Jennings  5 , Joshua C Mell  3 , Michael E Pichichero  6 , Allen F Ryan  7 , Hilda Tateossian  8 , Garth D Ehrlich  9
Affiliations
Review

Panel 3: Genomics, precision medicine and targeted therapies

Regie Lyn P Santos-Cortez et al. Int J Pediatr Otorhinolaryngol. 2020 Mar.

Abstract

Objective: To review the most recent advances in human and bacterial genomics as applied to pathogenesis and clinical management of otitis media.

Data sources: PubMed articles published since the last meeting in June 2015 up to June 2019.

Review methods: A panel of experts in human and bacterial genomics of otitis media was formed. Each panel member reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The panel met at the 20th International Symposium on Recent Advances in Otitis Media in June 2019, discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members.

Conclusion: Trans-disciplinary approaches applying pan-omic technologies to identify human susceptibility to otitis media and to understand microbial population dynamics, patho-adaptation and virulence mechanisms are crucial to the development of novel, personalized therapeutics and prevention strategies for otitis media.

Implications for practice: In the future otitis media prevention strategies may be augmented by mucosal immunization, combination vaccines targeting multiple pathogens, and modulation of the middle ear microbiome. Both treatment and vaccination may be tailored to an individual's otitis media phenotype as defined by molecular profiles obtained by using rapidly developing techniques in microbial and host genomics.

Keywords: Genome-wide association study; Metagenomics; Microbiome; Otitis media; Otitis-prone; Precision medicine.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest Dr. Allen F. Ryan is a Co-founder of and equity holder in Otonomy, Inc., a company that develops slow-release compounds for local delivery of medications to the middle and inner ear. The authors declare no competing interests.

Figures

Fig. 1.
Fig. 1.
Analysis of the Critical Assessment of Metagenome Interpretation community (>250 species) demonstrated the ability of MDx to identify and determine abundances of hundreds of species over >3 logs of variance. Reproduced from reference which is an author owned paper
Fig. 2.
Fig. 2.
Twenty bilateral microbiomes for chronic otitis media with effusion. The top 18 most prevalent species are shown as colored bars. Reproduced from reference which is an author owned paper
See this image and copyright information in PMC

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