Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr:79:104211.
doi: 10.1016/j.meegid.2020.104211. Epub 2020 Jan 30.

Novel coronavirus: From discovery to clinical diagnostics

Tung Phan  1
Affiliations

Novel coronavirus: From discovery to clinical diagnostics

Tung Phan. Infect Genet Evol. 2020 Apr.

Abstract

A novel coronavirus designated as 2019-nCoV first appeared in Wuhan, China in late December 2019. Dozens of people died in China, and thousands of people infected as 2019-nCoV continues to spread around the world. We have described the discovery, emergence, genomic characteristics, and clinical diagnostics of 2019-nCoV.

Keywords: Bat; China; Pneumonia; coronavirus.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The author declares no competing financial interests.

Figures

Fig. 1
Fig. 1
Pairwise sliding window of percent nucleotide similarity of 2019-nCoV (GenBank accession number MN908947) aligned with bat SARS-like coronavirus (Genbank accession number MG772933), MERS-CoV (Genbank accession number KT006149), HCoV-229E (Genbank accession number KF514433), HCoV-HKU1 (Genbank accession number KF430201), HCoV-NL63 (Genbank accession number KF530112), and HCoV-OC43 (Genbank accession number KF530098).
See this image and copyright information in PMC

References

    1. Babady N.E., England M.R., Jurcic Smith K.L., He T., Wijetunge D.S., Tang Y.W., Chamberland R.R., Menegus M., Swierkosz E.M., Jerris R.C., Greene W. Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs. J. Clin. Microbiol. 2018;56 pii: e01658–17. - PMC - PubMed
    1. Beckmann C., Hirsch H.H. Comparing Luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens. J. Med. Virol. 2016;88:1319–1324. - PMC - PubMed
    1. Fung T.S., Liu D.X. Human coronavirus: host-pathogen interaction. Annu. Rev. Microbiol. 2019;73:529–557. - PubMed
    1. Huang H.S., Tsai C.L., Chang J., Hsu T.C., Lin S., Lee C.C. Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis. Clin. Microbiol. Infect. 2018;24:1055–1063. - PMC - PubMed
    1. Luk H.K.H., Li X., Fung J., Lau S.K.P., Woo P.C.Y. Molecular epidemiology, evolution and phylogeny of SARS coronavirus. Infect. Genet. Evol. 2019:21–30. - PMC - PubMed

Publication types