Novel coronavirus: From discovery to clinical diagnostics

doi:10.1016/j.meegid.2020.104211

. 2020 Apr:79:104211.

doi: 10.1016/j.meegid.2020.104211. Epub 2020 Jan 30.

Novel coronavirus: From discovery to clinical diagnostics

Tung Phan¹

Affiliations

Affiliation

¹ Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: phantg@upmc.edu.

PMID: 32007627
PMCID: PMC7129799
DOI: 10.1016/j.meegid.2020.104211

Novel coronavirus: From discovery to clinical diagnostics

Tung Phan. Infect Genet Evol. 2020 Apr.

. 2020 Apr:79:104211.

doi: 10.1016/j.meegid.2020.104211. Epub 2020 Jan 30.

Author

Tung Phan¹

Affiliation

¹ Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: phantg@upmc.edu.

PMID: 32007627
PMCID: PMC7129799
DOI: 10.1016/j.meegid.2020.104211

Abstract

A novel coronavirus designated as 2019-nCoV first appeared in Wuhan, China in late December 2019. Dozens of people died in China, and thousands of people infected as 2019-nCoV continues to spread around the world. We have described the discovery, emergence, genomic characteristics, and clinical diagnostics of 2019-nCoV.

Keywords: Bat; China; Pneumonia; coronavirus.

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Conflict of interest statement

Declaration of Competing Interest The author declares no competing financial interests.

Figures

**Fig. 1**
Pairwise sliding window of percent nucleotide similarity of 2019-nCoV (GenBank accession number MN908947) aligned with bat SARS-like coronavirus (Genbank accession number MG772933), MERS-CoV (Genbank accession number KT006149), HCoV-229E (Genbank accession number KF514433), HCoV-HKU1 (Genbank accession number KF430201), HCoV-NL63 (Genbank accession number KF530112), and HCoV-OC43 (Genbank accession number KF530098).

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References

1. Babady N.E., England M.R., Jurcic Smith K.L., He T., Wijetunge D.S., Tang Y.W., Chamberland R.R., Menegus M., Swierkosz E.M., Jerris R.C., Greene W. Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs. J. Clin. Microbiol. 2018;56 pii: e01658–17. - PMC - PubMed
1. Beckmann C., Hirsch H.H. Comparing Luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens. J. Med. Virol. 2016;88:1319–1324. - PMC - PubMed
1. Fung T.S., Liu D.X. Human coronavirus: host-pathogen interaction. Annu. Rev. Microbiol. 2019;73:529–557. - PubMed
1. Huang H.S., Tsai C.L., Chang J., Hsu T.C., Lin S., Lee C.C. Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis. Clin. Microbiol. Infect. 2018;24:1055–1063. - PMC - PubMed
1. Luk H.K.H., Li X., Fung J., Lau S.K.P., Woo P.C.Y. Molecular epidemiology, evolution and phylogeny of SARS coronavirus. Infect. Genet. Evol. 2019:21–30. - PMC - PubMed

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[1] Babady N.E., England M.R., Jurcic Smith K.L., He T., Wijetunge D.S., Tang Y.W., Chamberland R.R., Menegus M., Swierkosz E.M., Jerris R.C., Greene W. Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs. J. Clin. Microbiol. 2018;56 pii: e01658–17. - PMC - PubMed

[2] Babady N.E., England M.R., Jurcic Smith K.L., He T., Wijetunge D.S., Tang Y.W., Chamberland R.R., Menegus M., Swierkosz E.M., Jerris R.C., Greene W. Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs. J. Clin. Microbiol. 2018;56 pii: e01658–17. - PMC - PubMed

[3] Beckmann C., Hirsch H.H. Comparing Luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens. J. Med. Virol. 2016;88:1319–1324. - PMC - PubMed

[4] Beckmann C., Hirsch H.H. Comparing Luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens. J. Med. Virol. 2016;88:1319–1324. - PMC - PubMed

[5] Fung T.S., Liu D.X. Human coronavirus: host-pathogen interaction. Annu. Rev. Microbiol. 2019;73:529–557. - PubMed

[6] Fung T.S., Liu D.X. Human coronavirus: host-pathogen interaction. Annu. Rev. Microbiol. 2019;73:529–557. - PubMed

[7] Huang H.S., Tsai C.L., Chang J., Hsu T.C., Lin S., Lee C.C. Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis. Clin. Microbiol. Infect. 2018;24:1055–1063. - PMC - PubMed

[8] Huang H.S., Tsai C.L., Chang J., Hsu T.C., Lin S., Lee C.C. Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis. Clin. Microbiol. Infect. 2018;24:1055–1063. - PMC - PubMed

[9] Luk H.K.H., Li X., Fung J., Lau S.K.P., Woo P.C.Y. Molecular epidemiology, evolution and phylogeny of SARS coronavirus. Infect. Genet. Evol. 2019:21–30. - PMC - PubMed

[10] Luk H.K.H., Li X., Fung J., Lau S.K.P., Woo P.C.Y. Molecular epidemiology, evolution and phylogeny of SARS coronavirus. Infect. Genet. Evol. 2019:21–30. - PMC - PubMed

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Novel coronavirus: From discovery to clinical diagnostics

Affiliation

Novel coronavirus: From discovery to clinical diagnostics

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