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Review
. 2020 Apr 15:411:116706.
doi: 10.1016/j.jns.2020.116706. Epub 2020 Jan 23.

Leptomeningeal metastasis from solid tumors

Jigisha P Thakkar  1 , Priya Kumthekar  2 , Karan S Dixit  3 , Roger Stupp  4 , Rimas V Lukas  5
Affiliations
Review

Leptomeningeal metastasis from solid tumors

Jigisha P Thakkar et al. J Neurol Sci. .

Abstract

Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.

Keywords: Carcinomatous meningitis; Central nervous system metastases; Cerebrospinal fluid; Intrathecal chemotherapy; Leptomeningeal metastases.

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Conflict of interest statement

Declaration of Competing Interest Honoraria for consulting for Abbvie, Eisai. Honoraria for advisory board Monteris. Honoraria for medical editing Medlink Neurology, EBSCO Publishing.