Preimplantation genetic testing for aneuploidy (PGT-A)-finally revealed

Raoul Orvieto^{1

2}, Norbert Gleicher^{3

4

5

6}

Affiliations

¹ Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel. raoul.orvieto@sheba.health.gov.il.
² The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel. raoul.orvieto@sheba.health.gov.il.
³ The Center for Human Reproduction, New York, NY, 10021, USA.
⁴ Foundation for Reproductive Medicine, New York, NY, 10021, USA.
⁵ Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University, New York, NY, 10016, USA.
⁶ Department of Obstetrics and Gynecology, Vienna University of Medicine, 1090, Vienna, Austria.

PMID: 32008181
PMCID: PMC7125263
DOI: 10.1007/s10815-020-01705-w

Comment

Preimplantation genetic testing for aneuploidy (PGT-A)-finally revealed

Raoul Orvieto et al. J Assist Reprod Genet. 2020 Mar.

. 2020 Mar;37(3):669-672.

doi: 10.1007/s10815-020-01705-w. Epub 2020 Feb 2.

Authors

Raoul Orvieto^{1

2}, Norbert Gleicher^{3

4

5

6}

Affiliations

¹ Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel. raoul.orvieto@sheba.health.gov.il.
² The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel. raoul.orvieto@sheba.health.gov.il.
³ The Center for Human Reproduction, New York, NY, 10021, USA.
⁴ Foundation for Reproductive Medicine, New York, NY, 10021, USA.
⁵ Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University, New York, NY, 10016, USA.
⁶ Department of Obstetrics and Gynecology, Vienna University of Medicine, 1090, Vienna, Austria.

PMID: 32008181
PMCID: PMC7125263
DOI: 10.1007/s10815-020-01705-w

No abstract available

Keywords: Intention to treat; Live-birth rate; PGS; PGT-A; RCT.

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Figures

**Fig. 1**
Enrollment, assignment, treatment, and analysis process of study and control patients. a Original START study. b Corrected analysis in this submission. PGT-A: preimplantation genetic testing for aneuploidy

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Comment on

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Munné S, Kaplan B, Frattarelli JL, Child T, Nakhuda G, Shamma FN, Silverberg K, Kalista T, Handyside AH, Katz-Jaffe M, Wells D, Gordon T, Stock-Myer S, Willman S; STAR Study Group. Munné S, et al. Fertil Steril. 2019 Dec;112(6):1071-1079.e7. doi: 10.1016/j.fertnstert.2019.07.1346. Epub 2019 Sep 21. Fertil Steril. 2019. PMID: 31551155 Clinical Trial.

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References

1. American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee Female age-related fertility decline. Committee Opinion No. 589. Fertil Steril. 2014;101:633–634. doi: 10.1016/j.fertnstert.2013.12.032. - DOI - PubMed
1. Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wof G, White M, et al. Preimplantation diagnosis of common aneuploidies by the first- and second-polar body FISG analysis. J Assist Reprod Genet. 1998;15:285–289. doi: 10.1023/A:1022592427128. - DOI - PMC - PubMed
1. Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, Vogel NE, Arts EG, de Vries JW, Bossuyt PM, Buys CH, Heineman MJ, Repping S, van der Veen F. In vitro fertilization with preimplantation genetic screening. N Engl J Med. 2007;357(1):9–17. doi: 10.1056/NEJMoa067744. - DOI - PubMed
1. Mastenbroek S, Twisk M, van der Veen F, Repping S. Preimplantation genetic screening: a systematic review. Hum Reprod Update. 2011;17:454–466. doi: 10.1093/humupd/dmr003. - DOI - PubMed
1. Orvieto R, Gleicher N. Should preimplantation genetic screening (PGS) be implemented to routine IVF practice? J Assist Reprod Genet. 2016;33(14):1445–1448. doi: 10.1007/s10815-016-0801-6. - DOI - PMC - PubMed

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Preimplantation genetic testing for aneuploidy (PGT-A)-finally revealed

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Preimplantation genetic testing for aneuploidy (PGT-A)-finally revealed

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