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Meta-Analysis
. 2020 Jun;30(6):2173-2185.
doi: 10.1007/s11695-020-04429-z.

Effects of Surgical and Non-surgical Weight Loss on Migraine Headache: a Systematic Review and Meta-Analysis

Angelo Di Vincenzo  1 , Marco Beghetto  1 , Roberto Vettor  1 , Claudio Tana  2 , Marco Rossato  1 , Dale S Bond  3 , Claudio Pagano  4
Affiliations
Meta-Analysis

Effects of Surgical and Non-surgical Weight Loss on Migraine Headache: a Systematic Review and Meta-Analysis

Angelo Di Vincenzo et al. Obes Surg. 2020 Jun.

Abstract

Background: The aim of this study was to perform a meta-analysis on the effect of weight loss obtained by bariatric surgery or behavioral intervention on migraine frequency and indices of severity.

Materials and methods: A search through Pubmed/Medline, ISI-web of knowledge, and Google Scholar retrieved 10 studies (n = 473). Selected outcomes were Headache Frequency, Pain Severity, Disability, and Attack Duration while BMI, BMI change, type of intervention (bariatric vs. behavioral), and type of population (adult vs. pediatric) were used for moderators and meta-regression analysis.

Results: Random effect meta-analysis shows that weight loss yields significant reductions in Headache Frequency (ES - 0.78, p < 0.0001), Pain Severity (ES - 1.04, p < 0.0001), Disability (ES -0.68, p < 0.0001), and Attack Duration (ES - 0.25, p = 0.017). Improvement in migraine was not correlated either to the degree of obesity at baseline or the degree of weight reduction. The effect on migraine was similar when weight reduction was obtained with bariatric surgery or behavioral intervention and was comparable in adult and pediatric populations.

Conclusions: Weight loss improves characteristics of migraine headache in patients who have obesity independently of the type of intervention and the amount of weight loss. The mechanisms underlying the link between obesity, weight loss, and migraine headache may include chronic inflammation, obesity comorbidities, and overlapping behavioral and psychological risk factors.

Keywords: Bariatric; Migraine; Obesity; Weight loss.

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References

    1. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–81. - DOI
    1. Bigal ME, Lipton RB. The epidemiology, burden, and comorbidities of migraine. Neurol Clin. 2009;27(2):321–34. - DOI
    1. Stovner LJ, Andree CJ. Prevalence of headache in Europe: a review for the Eurolight project. Headache Pain. 2010;11(4):289–99. - DOI
    1. Buse DC, Greisman JD, Baigi K, et al. Migraine progression: a systematic review. Headache. 2019;59(3):306–38. - DOI
    1. Peterlin BL, Rosso AL, Rapoport AM, et al. Obesity and migraine: the effect of age, gender and adipose tissue distribution. Headache. 2010;50(1):52–62. - DOI

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