Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;85(24):9679-82.
doi: 10.1073/pnas.85.24.9679.

Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer

P D Burbelo  1 , G R Martin, Y Yamada
Affiliations

Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer

P D Burbelo et al. Proc Natl Acad Sci U S A. 1988 Dec.

Abstract

Collagen IV is the major structural component of basement membranes and is a heterotrimer composed of two alpha 1(IV) and one alpha 2(IV) chains. Most collagen genes are dispersed in the human genome, such as the genes for collagen I, which are located on chromosomes 7 [alpha 1(I)] and 17 [alpha 2(I)]. In contrast, we have found that the murine alpha 1(IV) and alpha 2(IV) collagen chain genes exist in a head-to-head arrangement on opposite strands separated by 130 base pairs. By transfecting various portions of these genes into cells, we have found that transcription of the alpha 1(IV) and alpha 2(IV) genes is regulated by a bidirectional promoter located between the two genes working in concert with an enhancer located in the first intron of the alpha 1(IV) chain gene.

PubMed Disclaimer

References

    1. J Biol Chem. 1988 Sep 5;263(25):12310-4 - PubMed
    1. J Biol Chem. 1988 Jun 25;263(18):8706-9 - PubMed
    1. Virology. 1973 Apr;52(2):456-67 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Mol Cell Biol. 1982 Sep;2(9):1044-51 - PubMed

Publication types

Associated data