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Review
. 2019;15(9):819-830.
doi: 10.2174/1573405614666180327122548.

The Established Nuclear Medicine Modalities for Imaging of Bone Metastases

Nazish Jabeen  1 , Rashid Rasheed  2 , Asma Rafique  1 , Ghulam Murtaza  1
Affiliations
Review

The Established Nuclear Medicine Modalities for Imaging of Bone Metastases

Nazish Jabeen et al. Curr Med Imaging Rev. 2019.

Abstract

Background: The skeleton is one of the frequent site of metastases in advanced cancer. Prostate, breast and renal cancers mostly metastasize to bone.

Discussion: Malignant tumors lead to significant morbidity and mortality. Identification of bone lesions is a crucial step in diagnosis of disease at early stage, monitoring of disease progression and evaluation of therapy. Diagnosis of cancer metastases is based on uptake of bone-targeted radioactive tracer at different bone remodeling sites.

Conclusion: This manuscript summarizes already established and evolving nuclear medicine modalities (e.g. bone scan, SPECT, SPECT/CT, PET, PET/CT) for imaging of bone metastases.

Keywords: Malignant tumors; bone lesion; cancer metastasis; diagnosis; morbidity; mortality; radioactive tracer.

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