Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;85(24):9778-82.
doi: 10.1073/pnas.85.24.9778.

Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism

G C Mueller  1 , M F Fleming, M A LeMahieu, G S Lybrand, K J Barry
Affiliations

Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism

G C Mueller et al. Proc Natl Acad Sci U S A. 1988 Dec.

Abstract

Phosphatidylethanol, whose synthesis is catalyzed by a phospholipase D in a transphosphatidylation reaction, is a unique metabolite of ethanol. Phorbol 12-tetradecanoate 13-acetate, a tumor-promoting phorbol ester and stimulator of protein kinase C, activates this enzyme in peripheral blood lymphocytes. This system has been developed into an assay for measuring the potential of this pathway in human subjects. A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatidylethanol synthesis in this population is significantly elevated over that of control subjects.

PubMed Disclaimer

References

    1. Arch Gen Psychiatry. 1973 Feb;28(2):238-43 - PubMed
    1. Exp Cell Res. 1974 Jun;86(2):333-41 - PubMed
    1. J Stud Alcohol. 1979;40(1):89-116 - PubMed
    1. FEBS Lett. 1983 Feb 7;152(1):24-8 - PubMed
    1. Carcinogenesis. 1983 Oct;4(10):1247-51 - PubMed

Publication types