Lung Cancer in Women: A Modern Epidemic

Abstract

Lung cancer in women is a modern epidemic and a major health crisis. Cigarette smoking remains the most important risk factor for lung cancer, and unfortunately smoking rates are either stabilized or continue to increase among women. Women may not be more susceptible to the carcinogenic effects of tobacco, but the biology of lung cancer differs between the sexes. This paper summarizes the biological sex differences in lung cancer, including molecular abnormalities, growth factor receptors, hormonal influences, DNA repair capacity, as well as differences in the histology and treatment outcomes of lung cancer in women.

Keywords: Epidermal growth factor receptor; Growth factor receptors; Hormonal factors; Lung cancer in nonsmokers; Lung cancer in women; Non-small cell lung cancer in women; Sex differences in lung cancer.