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. 2020 Feb;19(2):891-896.
doi: 10.3892/etm.2019.8274. Epub 2019 Dec 4.

Assessment of the value of 3D-DSA combined with neurointerventional thrombolysis in the treatment of senile cerebrovascular occlusion

Song Jiao  1 , Ling Gong  2 , Zhongbo Wu  1 , Linrui Zhu  3 , Jinjian Hu  4 , Bo Tang  1 , Shengtao Yao  1
Affiliations

Assessment of the value of 3D-DSA combined with neurointerventional thrombolysis in the treatment of senile cerebrovascular occlusion

Song Jiao et al. Exp Ther Med. 2020 Feb.

Abstract

Assessment of the value of three-dimensional digital subtraction angiography (3D-DSA) combined with neurointerventional thrombolysis in the treatment of senile cerebrovascular occlusion was investigated. A total of 129 patients with senile cerebrovascular occlusion admitted to the Affiliated Hospital of Zunyi Medical University from August 2015 to September 2017 were collected. Among them, 69 patients who underwent neurointerventional catheter thrombolysis under 3D-DSA were included in the study group, and 60 patients treated with neurointerventional thrombolysis were the control group. The levels of inflammatory cytokines IL-6, IL-1β and IL-8 in the two groups were measured by enzyme linked immunosorbent assay (ELISA) before treatment (T0), 7 days (7d) after treatment (T1) and 14 days (14d) after treatment (T2). The score of the National Institute of Health Stroke Scale and the clinical efficacy of patients in the two groups were compared before and after treatment, and Barthel index (BI) was used for investigation before and after treatment. The recurrence rate of disease in the two groups within 1 year was recorded. At T1, IL-6, IL-1β and IL-8 in the study group were significantly lower than those in the control group (P<0.05). The NIHSS score in the study group was lower than that in the control group after treatment (P<0.05). The BI score in the study group was significantly higher than that in the control group after treatment (P<0.05). After the prognostic follow-up, the disease recurrence rate of the study group was significantly lower than that of the control group (P<0.05). In conclusion, 3D-DSA combined with neurointerventional thrombolysis can significantly reduce the expression of inflammatory cytokines and improve the quality of life in patients with cerebrovascular occlusion, which has a high clinical value.

Keywords: cerebrovascular occlusion; neurointerventional thrombolysis; three-dimensional digital subtraction angiography; value assessment.

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Figures

Figure 1.
Figure 1.
(A) Changes of inflammatory cytokine IL-6 level before treatment (T0), 7d after treatment (T1) and 14d after treatment of patients in the two groups. (B) Changes of inflammatory cytokine IL-1β level before treatment (T0), 7d after treatment (T1) and 14d after treatment of patients in the two groups. (C) Changes of inflammatory cytokine IL-8 level before treatment (T0), 7d after treatment (T1) and 14d after treatment of patients in the two groups. *P<0.05 compared with before treatment; #P<0.05 compared with study group; ^P<0.05, 14d after treatment compared with 7d after treatment; &P<0.05 14d after treatment compared with before treatment.
Figure 2.
Figure 2.
The NIHSS scores before treatment in four time periods (2 h, 1d, 7d and 14d) after treatment in the two groups were compared. *P<0.05 compared with before treatment; @P<0.05 compared with 2 h after treatment; ^P<0.05 compared with 1d after treatment; &P<0.05 compared with 7d after treatment; #P<0.05 compared with the study group of the same time.
Figure 3.
Figure 3.
Comparison of Barthel index score between the two groups. *P<0.05 compared with before treatment; &P<0.05 compared with study group.
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