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. 2019 Oct 15;7(21):3716-3720.
doi: 10.3889/oamjms.2019.757. eCollection 2019 Nov 15.

The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer

Indri Windarti  1 , Wirsma Arif Harahap  2 , Ricvan Dana Nindrea  3 , Eti Yerizel  4 , Primariadewi Rustamadji  5
Affiliations

The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer

Indri Windarti et al. Open Access Maced J Med Sci. .

Abstract

Aim: This study aims to determine the prognostic significance of phosphatase and tensin homolog (PTEN) loss in breast cancer.

Methods: We conducted a meta-analysis study. Sample of this study were research articles that evaluated PTEN loss and prognosis in breast cancer patients. We searched for relevant studies published in PubMed and Proquest from January 2010 to July 2018. We reviewed studies that examined the association between immunohistochemical expression of PTEN and breast cancer prognosis using meta-analysis methods. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3).

Results: There were 7 studies conducted a systematic review then continued to evaluate the association of PTEN loss and breast cancer prognosis by meta-analysis. There was a significant association of PTEN loss with poor prognosis of breast cancer (RR = 0.76 [95% CI 0.59-0.98 p <0.07), and there was not any significant publication bias for studies included.

Conclusion: This study confirmed PTEN loss is an important independent factor for breast cancer prognosis.

Keywords: Breast cancer; Immunohistochemical; PTEN; Prognosis.

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Figures

Figure 1
Figure 1
Flow diagram research procedure
Figure 2
Figure 2
Forest plots the association of PTEN loss and breast cancer prognosis
Figure 3
Figure 3
Funnel plots the association of PTEN loss and breast cancer prognosis
See this image and copyright information in PMC

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