Society for Translational Medicine consensus on postoperative management of EGFR-mutant lung cancer (2019 edition)

Wenhua Liang^{1

2}, Kaican Cai³, Chun Chen⁴, Haiquan Chen^{5

6}, Wentao Fang⁶, Junke Fu⁷, Xiangning Fu⁸, Shugeng Gao⁹, Jian Hu¹⁰, Yunchao Huang¹¹, Ganning Jiang¹², Wenjie Jiao¹³, Shanqing Li¹⁴, Gaofeng Li¹¹, Hecheng Li¹⁵, Hui Li¹⁶, Xiaofei Li¹⁷, Naixin Liang¹⁴, Deruo Liu¹⁸, Hongxu Liu¹⁹, Jun Liu^{1

2}, Lunxu Liu²⁰, Yang Liu²¹, Qingquan Luo²², Haitao Ma²³, Weimin Mao²⁴, Zhongmin Peng²⁵, Guibin Qiao²⁶, Guoguang Shao²⁷, Lijie Tan²⁸, Qunyou Tan²⁹, Qun Wang²⁸, Changli Wang³⁰, Qingchen Wu³¹, Shidong Xu³², Songtao Xu²⁸, Lin Xu³³, Yue Yang³⁴, Fenglei Yu³⁵, Baijiang Zhang³⁶, Lanjun Zhang³⁷, Bo Zhao⁸, Xiuyi Zhi³⁸, Alessandro Brunelli³⁹, René Horsleben Petersen⁴⁰, Chia-Chuan Liu⁴¹, Biagio Ricciuti⁴², Giulio Metro⁴², Alessandro Tuzi⁴³, Matteo B Suter⁴³, Matthew Evison⁴⁴, Nobuhiko Seki⁴⁵, Shinji Sasada⁴⁶, Takhiro Izumo⁴⁷, William Chi-Shing Cho⁴⁸, Jianxing He^{1

2}; written on behalf of National Clinical Research Center for Respiratory Disease; Thoracic Surgery Branch of China International Exchange and Promotion Association for Medical and Healthcare; Chinese Alliance Against Lung Cancer; AME Thoracic Surgery Collaborative Group

Affiliations

¹ Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
² Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China.
³ Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
⁴ Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350000, China.
⁵ Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
⁶ Department of Thoracic Surgery, Shanghai Chest Hospital, Jiao Tong University, Shanghai 200030, China.
⁷ Department of Thoracic Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
⁸ Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
⁹ Department of Thoracic Surgical Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Cancer Center, Beijing 100021, China.
¹⁰ Department of Thoracic Surgery, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
¹¹ Department of Thoracic and Cardiovascular Surgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming 650118, China.
¹² Department of Thoracic Surgery, Shanghai Pulmonary Hospital of Tongji University, Shanghai 200433, China.
¹³ Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266071, China.
¹⁴ Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medicine, Beijing 100730, China.
¹⁵ Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
¹⁶ Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Beijing 100020, China.
¹⁷ Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
¹⁸ Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
¹⁹ Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
²⁰ Department of Cardiovascular and Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
²¹ Department of Thoracic Surgery, The PLA General Hospital, Beijing 100853, China.
²² Shanghai Lung Tumor Clinical Medical Center, Shanghai 200030, China.
²³ Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
²⁴ Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
²⁵ Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan 250021, China.
²⁶ Department of Thoracic Surgery, Guangzhou General Hospital of Guangzhou Military Area Command, Guangzhou 510010, China.
²⁷ Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, China.
²⁸ Department of Thoracic Surgery, Shanghai Zhongshan Hospital of Fudan University, Shanghai 200032, China.
²⁹ Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China.
³⁰ Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China.
³¹ Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
³² Department of Thoracic surgery, Harbin Medical University Cancer Hospital, Harbin 150040, China.
³³ Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing 210009, China.
³⁴ Department of Thoracic Surgery, Beijing Cancer Hospital, Beijing 100142, China.
³⁵ Department of Cardiovascular Surgery, Second Xiangya Hospital of Central South University, Changsha 410011, China.
³⁶ Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, China.
³⁷ Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
³⁸ Department of Thoracic Surgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
³⁹ Department of Thoracic Surgery, St. James's University Hospital, Leeds, UK.
⁴⁰ Department of Cardiothoracic Surgery, Copenhagen University, Rigshospitalet, Copenhagen, Denmark.
⁴¹ Division of Thoracic Surgery, Department of Surgery, Sun Yat-Sen Cancer Center, Taipei, Taiwan, China.
⁴² Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia, Italy.
⁴³ Medical Oncology, ASST Sette Laghi, Varese, Italy.
⁴⁴ North West Lung Centre, University Hospital of South Manchester, Wythenshawe, UK.
⁴⁵ Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.
⁴⁶ Department of Respiratory Medicine, Tokyo Saiseikai Central Hospital, Minato-ku, Tokyo, Japan.
⁴⁷ Department of Respiratory Medicine, Japanese Red Cross Medical Center, Shibuya-ku, Tokyo, Japan.
⁴⁸ Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China.

PMID: 32010594
PMCID: PMC6976380
DOI: 10.21037/tlcr.2019.12.14

Review

Society for Translational Medicine consensus on postoperative management of EGFR-mutant lung cancer (2019 edition)

Wenhua Liang et al. Transl Lung Cancer Res. 2019 Dec.

. 2019 Dec;8(6):1163-1173.

doi: 10.21037/tlcr.2019.12.14.

Authors

Affiliations

¹ Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
² Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China.
³ Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
⁴ Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350000, China.
⁵ Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
⁶ Department of Thoracic Surgery, Shanghai Chest Hospital, Jiao Tong University, Shanghai 200030, China.
⁷ Department of Thoracic Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
⁸ Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
⁹ Department of Thoracic Surgical Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Cancer Center, Beijing 100021, China.
¹⁰ Department of Thoracic Surgery, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
¹¹ Department of Thoracic and Cardiovascular Surgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming 650118, China.
¹² Department of Thoracic Surgery, Shanghai Pulmonary Hospital of Tongji University, Shanghai 200433, China.
¹³ Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266071, China.
¹⁴ Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medicine, Beijing 100730, China.
¹⁵ Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
¹⁶ Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Beijing 100020, China.
¹⁷ Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
¹⁸ Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
¹⁹ Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
²⁰ Department of Cardiovascular and Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
²¹ Department of Thoracic Surgery, The PLA General Hospital, Beijing 100853, China.
²² Shanghai Lung Tumor Clinical Medical Center, Shanghai 200030, China.
²³ Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
²⁴ Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
²⁵ Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan 250021, China.
²⁶ Department of Thoracic Surgery, Guangzhou General Hospital of Guangzhou Military Area Command, Guangzhou 510010, China.
²⁷ Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, China.
²⁸ Department of Thoracic Surgery, Shanghai Zhongshan Hospital of Fudan University, Shanghai 200032, China.
²⁹ Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China.
³⁰ Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China.
³¹ Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
³² Department of Thoracic surgery, Harbin Medical University Cancer Hospital, Harbin 150040, China.
³³ Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing 210009, China.
³⁴ Department of Thoracic Surgery, Beijing Cancer Hospital, Beijing 100142, China.
³⁵ Department of Cardiovascular Surgery, Second Xiangya Hospital of Central South University, Changsha 410011, China.
³⁶ Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, China.
³⁷ Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
³⁸ Department of Thoracic Surgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
³⁹ Department of Thoracic Surgery, St. James's University Hospital, Leeds, UK.
⁴⁰ Department of Cardiothoracic Surgery, Copenhagen University, Rigshospitalet, Copenhagen, Denmark.
⁴¹ Division of Thoracic Surgery, Department of Surgery, Sun Yat-Sen Cancer Center, Taipei, Taiwan, China.
⁴² Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia, Italy.
⁴³ Medical Oncology, ASST Sette Laghi, Varese, Italy.
⁴⁴ North West Lung Centre, University Hospital of South Manchester, Wythenshawe, UK.
⁴⁵ Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.
⁴⁶ Department of Respiratory Medicine, Tokyo Saiseikai Central Hospital, Minato-ku, Tokyo, Japan.
⁴⁷ Department of Respiratory Medicine, Japanese Red Cross Medical Center, Shibuya-ku, Tokyo, Japan.
⁴⁸ Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China.

PMID: 32010594
PMCID: PMC6976380
DOI: 10.21037/tlcr.2019.12.14

Erratum in

Erratum to Society for Translational Medicine consensus on postoperative management of EGFR-mutant lung cancer (2019 edition).
[No authors listed] [No authors listed] Transl Lung Cancer Res. 2020 Jun;9(3):944. doi: 10.21037/tlcr.2020.03.39. Transl Lung Cancer Res. 2020. PMID: 32676360 Free PMC article.

No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Comment in

Implications of the success of EGFR-targeted therapy in advanced non-small cell lung cancer for its application to the adjuvant setting.
Takeda M. Takeda M. J Thorac Dis. 2020 Aug;12(8):4553-4555. doi: 10.21037/jtd-2020-46. J Thorac Dis. 2020. PMID: 32944373 Free PMC article. No abstract available.
Postoperative management for non-small cell lung cancer harboring EGFR mutations.
Tanaka F, Yoneda K, Takenaka M. Tanaka F, et al. J Thorac Dis. 2020 Aug;12(8):4556-4560. doi: 10.21037/jtd-2020-45. J Thorac Dis. 2020. PMID: 32944374 Free PMC article. No abstract available.
Society for Translational Medicine consensus (2019 edition) shows an option for postoperative management of EGFR-mutant lung cancer.
Nagano T, Tachihara M, Hazama D, Nishimura Y. Nagano T, et al. J Thorac Dis. 2020 Aug;12(8):4561-4563. doi: 10.21037/jtd.2020.04.34. J Thorac Dis. 2020. PMID: 32944375 Free PMC article. No abstract available.
Adjuvant EGFR-TKIs-based therapy: are we ready?
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Adjuvant TKI treatment of EGFR-mutant lung cancer-already ripe for decision?
Kauffmann-Guerrero D. Kauffmann-Guerrero D. Transl Lung Cancer Res. 2020 Aug;9(4):964-966. doi: 10.21037/tlcr.2020.04.13. Transl Lung Cancer Res. 2020. PMID: 32953476 Free PMC article. No abstract available.
Use of adjuvant EGFR tyrosine kinase inhibitors in early stage EGFR-mutant non-small cell lung cancer: is the evidence strong enough?
Lemmon C, Pennell NA. Lemmon C, et al. J Thorac Dis. 2020 Sep;12(9):5042-5045. doi: 10.21037/jtd-20-1817. J Thorac Dis. 2020. PMID: 33145076 Free PMC article. No abstract available.
One step too far in the right direction: The Society for Translational Medicine 2019 consensus on postoperative management of EGFR-mutant lung cancer.
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It takes all sorts to make a world: geographical differences and the future perspective of molecular testing in non-small cell lung cancer.
Bertoglio P, Costardi L, Viti A, Ruffini E, Guerrera F. Bertoglio P, et al. J Thorac Dis. 2020 Sep;12(9):5050-5052. doi: 10.21037/jtd-2020-49. J Thorac Dis. 2020. PMID: 33145078 Free PMC article. No abstract available.
Adjuvant EGFR TKIs in NSCLC harboring EGFR mutations: looking for a consensus way.
Attili I, Passaro A, Spaggiari L, Spitaleri G, de Marinis F. Attili I, et al. Ann Transl Med. 2020 Sep;8(17):1111. doi: 10.21037/atm.2020.04.35. Ann Transl Med. 2020. PMID: 33145330 Free PMC article. No abstract available.
EGFR and non-small cell lung cancer: implications for surgical practice.
Varela G, Novoa NM. Varela G, et al. Ann Transl Med. 2020 Sep;8(17):1115. doi: 10.21037/atm.2020.04.47. Ann Transl Med. 2020. PMID: 33145334 Free PMC article. No abstract available.
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Shepherd AF, Preeshagul IR, Shaverdian N, Wu AJ, Gelblum DY, Gomez DR, Rimner A, Simone CB 2nd. Shepherd AF, et al. Ann Transl Med. 2020 Dec;8(23):1613. doi: 10.21037/atm-20-3982. Ann Transl Med. 2020. PMID: 33437812 Free PMC article. No abstract available.
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Society for Translational Medicine consensus on postoperative management of EGFR-mutant lung cancer (2019 edition)

Affiliations

Society for Translational Medicine consensus on postoperative management of EGFR-mutant lung cancer (2019 edition)

Authors

Affiliations

Erratum in

Conflict of interest statement

Comment in

References

Publication types

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous