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. 2020 Jan 27;6(1):00289-2019.
doi: 10.1183/23120541.00289-2019. eCollection 2020 Jan.

Validation of online Asthma Control Questionnaire and Asthma Quality of Life Questionnaire

Rishi J Khusial  1 , Persijn J Honkoop  1 , Victor van der Meer  1 , Jiska B Snoeck-Stroband  1 , Jacob K Sont  1
Affiliations

Validation of online Asthma Control Questionnaire and Asthma Quality of Life Questionnaire

Rishi J Khusial et al. ERJ Open Res. .

Abstract

Objective: Several newly developed eHealth applications use online questionnaires to monitor asthma control. The Asthma Control Questionnaire (ACQ) and Asthma Quality of Life Questionnaire (AQLQ) are two such commonly used questionnaires. These questionnaires are validated for use on paper. This study aims to validate them by assessing the agreement between online and paper versions of the ACQ and AQLQ.

Methods: Patients (aged 18 years and older) from the Self-Management in Asthma Supported by Hospitals, ICT, Nurses and General Practitioners (SMASHING)-trial and Davos@home study were included in this study. Patients completed both the paper and online Dutch versions of the ACQ and AQLQ in a random order within a 2-week interval. Agreement between the different versions was assessed with paired t-tests, intraclass correlation coefficients and Bland-Altman plots.

Results: In total 44 patients were eligible for analysis. The mean difference between the paper and online versions of the ACQ was 0.04 (p=0.40) and for the AQLQ it was 0.08 (p=0.06). The intraclass correlation coefficient scores were 0.94 for the ACQ and 0.95 for the AQLQ.

Conclusion: The online versions of the ACQ and AQLQ show high levels of agreement with the paper versions and can therefore be safely used in eHealth applications to respectively monitor asthma control and quality of life.

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Conflict of interest statement

Conflict of interest: R.J. Khusial has nothing to disclose. Conflict of interest: P.J. Honkoop reports personal fees for a medical education video for GPs and pharmacists from E-wise, outside the submitted work. Conflict of interest: V. van der Meer has nothing to disclose. Conflict of interest: J.B. Snoeck-Stroband has nothing to disclose. Conflict of interest: J.K. Sont has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Flowchart participant enrolment. SMASHING: Self-Management in Asthma Supported by Hospitals, ICT, Nurses and General Practitioners; AQLQ: Asthma Quality of Life Questionnaire; ACQ: Asthma Control Questionnaire.
FIGURE 2
FIGURE 2
Identity plots. The paper questionnaires plotted against the online versions for the a) Asthma Control Questionnaire (ACQ) and b) Asthma Quality of Life Questionnaire (AQLQ). The x=y line depicts an identical result for the paper and online versions. The agreement between the two versions is acceptable if the measurement falls between the upper and lower limits of the minimal clinically important difference (MCID) (mean difference ±0.5).
FIGURE 3
FIGURE 3
Bland–Altman plots for the a) Asthma Control Questionnaire (ACQ) and b) Asthma Quality of Life Questionnaire (AQLQ). ---: mean difference. The area between the dashed lines (– – –) represents the minimal clinically important difference range (mean difference ±0.5) and the solid lines (—) represent the limits of agreement.
See this image and copyright information in PMC

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