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Review
. 2020 Jan 27;21(3):811.
doi: 10.3390/ijms21030811.

Lysosomal Abnormalities in Cardiovascular Disease

Congwu Chi  1   2   3   4 , Andrew S Riching  1   2   3   4 , Kunhua Song  1   2   3   4
Affiliations
Review

Lysosomal Abnormalities in Cardiovascular Disease

Congwu Chi et al. Int J Mol Sci. .

Abstract

The lysosome, a key organelle for cellular clearance, is associated with a wide variety of pathological conditions in humans. Lysosome function and its related pathways are particularly important for maintaining the health of the cardiovascular system. In this review, we highlighted studies that have improved our understanding of the connection between lysosome function and cardiovascular diseases with an emphasis on a recent breakthrough that characterized a unique autophagosome-lysosome fusion mechanism employed by cardiomyocytes through a lysosomal membrane protein LAMP-2B. This finding may impact the development of future therapeutic applications.

Keywords: Danon disease; autophagy; cardiovascular disease; lysosome function.

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Conflict of interest statement

The authors declare no conflict of interest.

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