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. 2020 Jan 28;9(2):355.
doi: 10.3390/jcm9020355.

Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Retrospective Clinical and Radiological Outcomes of a Randomized Controlled Clinical Trial

Sameh Attia  1 , Clara Narberhaus  1 , Heidrun Schaaf  1 , Philipp Streckbein  1 , Jörn Pons-Kühnemann  2 , Christian Schmitt  3 , Friedrich Wilhelm Neukam  3 , Hans-Peter Howaldt  1 , Sebastian Böttger  1
Affiliations

Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Retrospective Clinical and Radiological Outcomes of a Randomized Controlled Clinical Trial

Sameh Attia et al. J Clin Med. .

Abstract

: The long-term clinical and radiological outcomes of dental implants inserted in augmented bone treated with platelet-rich plasma (PRP) has not been well addressed in the literature yet. This study is based on a collection of patients from a randomized controlled trial (RCT) that did not report any short-term positive effects of PRP on bone healing after sinus lift surgery using autologous iliac crest bone graft. This study aimed to evaluate the long-term impact of PRP regarding clinical and radiological outcomes on the inserted implants in the previous RCT. For this evaluation, we considered the following variables: plaque index, probing depth, bleeding index, mobility grade, Periotest® values, and radiological bone loss. Out of 53 patients (n = 306 implants) included in the previous study we were able to reinvestigate 37 patients (n = 210 implants) in two centers (31 in Giessen, Germany and 6 in Erlangen, Germany). Clinical and radiographic parameters suggested overall healthy conditions of the peri-implant tissue. The PRP-group and the control group did not differ significantly in the majority of the parameters. The overall evaluation showed that result data of the PRP-group was inferior to the control group in 64 percent of the evaluated parameters. The present study cannot provide evidence of a positive effect of PRP on the long-term implant clinical and radiological outcomes. In fact, a tendency towards inferior long-term results in the PRP-group was detected without reaching a significant threshold. Further controlled trials need to be conducted to investigate this correlation.

Keywords: Long-term result; PRP; Sinus lift; clinical outcome; dental Implant; radiological outcome.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Calibration of the panoramic X-ray for accurate measurement of the bone resorption. *: calibrated according to scale bar.
Figure 2
Figure 2
Number of patients included in this study versus number of drop-outs in the two clinics.
Figure 3
Figure 3
Number of implant in each implant system in both the platelet-rich plasma (PRP) and control sides.
Figure 4
Figure 4
The alveolar crest height at the follow-up examination between the PRP and control side (split-mouth evaluation).
Figure 5
Figure 5
Distribution of implant systems used in PRP and control groups (unilateral evaluation).
Figure 6
Figure 6
The alveolar crest height at the follow-up examination between the PRP and control sides (unilateral evaluation).
See this image and copyright information in PMC

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