Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan 29;17(3):839.
doi: 10.3390/ijerph17030839.

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training

Antonello Sica  1 , Paola Vitiello  2 , Andrea Ronchi  3 , Beniamino Casale  4 , Armando Calogero  5 , Evangelista Sagnelli  3 , Gilca Costa Nachtigal  6 , Teresa Troiani  1 , Renato Franco  3 , Giuseppe Argenziano  2 , Elvira Moscarella  2 , Caterina Sagnelli  3
Affiliations
Review

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training

Antonello Sica et al. Int J Environ Res Public Health. .

Abstract

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is part of a spectrum of cutaneous CD30+ lymphoproliferative disease that also includes lymphomatoid papulosis. It often occurs in elderly patients, presenting at a median age of 60 years, although it may occur at any age. It is a CD30+ T-cell neoplasm composed of large cells with anaplastic, pleomorphic, or immunoblastic morphology, with exclusively cutaneous onset and localization. The clinical course of pcALCL is predominantly indolent. Most elderly patients with lymphoma tend to have a sedentary lifestyle, which has a negative effect on their quality of life (QoL) and survival. Several studies indicate that exercise has a positive impact on QoL because it reduces peak oxygen consumption, improves physical capacity, increases self-esteem, reduces accumulated stress, and promotes relaxation. Therefore, particularly in indolent lymphomas, it is necessary to indicate a program of physical activity to be practiced systematically. Complete surgical excision and local radiotherapy are the first line gold standard in pcALCL with a solitary lesion.

Keywords: T-cell lymphomas; cutaneous lymphoma in the elderly; skin tumors; sport activity training.

PubMed Disclaimer

Conflict of interest statement

All the authors of the manuscript declare they have no conflicts of interest in connection with this paper.

Figures

Figure 1
Figure 1
Histological features of primary cutaneous anaplastic large cell lymphoma (pcALCL). (A) This skin punch biopsy is characterized by a dense lymphoid population filling the dermis, without significant epidermotropism. The epidermis shows secondary changes, including hyperkeratosis and papillomatosis (Hematoxylin and eosin (H&E), 2.4×). Inset: the neoplastic population is composed of large-sized cells with abundant, slightly eosinophilic cytoplasm and roundish, atypical nuclei. Two mitotic figures are evident in the center of the field. Some neutrophils and eosinophils are scattered in the context of the neoplastic population (H&E, 20×). The large cells are positive for CD3 (B), CD4 (C), and CD30 (D) immunohistochemical staining.
Figure 2
Figure 2
Clinical presentation of ALK- pcALCL with extensive ulcerated plaques located on the trunk and upper arms (a). Resolution of skin lesions, with central scarring and depigmentation after treatment (b).
Figure 3
Figure 3
ALK- pcALCL single localization on a leg.
See this image and copyright information in PMC

References

    1. Nikolaenko L., Zain J., Rosen S.T., Querfeld C. CD30-Positive Lymphoproliferative Disorders. Cancer Treat Res. 2019;176:249–268. - PubMed
    1. Melchers R.C., Willemze R., Bekkenk M.W., de Haas E.R.M., Horvath B., van Rossum M.M., Sanders C.J.G., Veraart J.C.J.M., Vermeer M.H., Quint K.D. In a multifunctional primary cutaneous anaplastic large cell lymphoma: Report of the Dutch Cutaneous Lymphoma Group. Br. J. Dermatol. 2018;179:724–731. doi: 10.1111/bjd.16501. - DOI - PubMed
    1. Kaseb H., Rajasurya V. Cancer, Anaplastic Large Cell Lymphoma (ALCL Ki 1+) [(accessed on 12 August 2019)]; Available online: https://www.ncbi.nlm.nih.gov/books/NBK537150/
    1. Lynch R.C., Gratzinger D., Advani R.H. Clinical Impact of the 2016 Update to the WHO Lymphoma Classification. Curr Treat Options Oncol. 2017;18:45. doi: 10.1007/s11864-017-0483-z. - DOI - PubMed
    1. Willemze R., Cerroni L., Kempf W., Berti E., Facchetti F., Swerdlow S.H., Jaffe E.S. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133:1703–1714. doi: 10.1182/blood-2018-11-881268. - DOI - PMC - PubMed