Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb 3;20(1):73.
doi: 10.1186/s12884-020-2759-8.

Effects of gestational diabetes mellitus on risk of adverse maternal outcomes: a prospective cohort study in Northwest Ethiopia

Achenef Asmamaw Muche  1   2 , Oladapo O Olayemi  3 , Yigzaw Kebede Gete  4
Affiliations

Effects of gestational diabetes mellitus on risk of adverse maternal outcomes: a prospective cohort study in Northwest Ethiopia

Achenef Asmamaw Muche et al. BMC Pregnancy Childbirth. .

Abstract

Background: Gestational diabetes mellitus is a leading medical condition woman encounter during pregnancy with serious short- and long-term consequences for maternal morbidity. However, limited evidence was available on potential impacts of gestational diabetes mellitus using updated international diagnostic criteria on adverse maternal outcomes. Therefore, this study aimed to assess the effects of gestational diabetes mellitus on the risk of adverse maternal outcomes in Northwest Ethiopia.

Methods: A prospective cohort study was conducted among pregnant women followed from pregnancy to delivery. Gestational diabetes mellitus status was determined by using a two-hour 75 g oral glucose tolerance test and based on updated international diagnostic criteria. Multivariable log-binomial model was used to examine the effects of gestational diabetes mellitus on the risk of adverse maternal outcomes.

Results: A total of 694 women completed the follow-up and included in the analysis. Women with gestational diabetes mellitus had a higher risk of composite adverse maternal outcome (ARR=1.58, 95% CI: 1.22, 2.04), caesarean delivery (ARR=1.67; 95%: 1.15, 2.44), pregnancy induced hypertension (ARR= 3.32; 95%: 1.55, 7.11), premature rupture of membranes (ARR= 1.83; 95%: 1.02, 3.27), antepartum hemorrhage (ARR= 2.10; 95%: 1.11, 3.98) and postpartum hemorrhage (ARR= 4.85; 95%:2.28, 10.30) compared to women without gestational diabetes mellitus.

Conclusions: Gestational diabetes mellitus increased the risk of adverse maternal outcomes. This implies that maternal care and intervention strategies relating to women with gestational diabetes mellitus should be strengthened.

Keywords: Gestational diabetes mellitus; adverse maternal outcome; antepartum hemorrhage; postpartum hemorrhage; pregnancy induced hypertension; premature rupture of membranes.

PubMed Disclaimer

Conflict of interest statement

The authors declared that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study participant flow of the prospective cohort of pregnant women in Gondar town public health facilities, Northwest Ethiopia March 2018- March, 2019
Fig. 2
Fig. 2
Adverse maternal outcomes among mothers with and without GDM among women completed the follow up from pregnancy through to delivery in Gondar town public health facilities, Northwest Ethiopia March 2018- March, 2019 (n = 694)
See this image and copyright information in PMC

References

    1. World Health Organization (WHO). Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. World Health Organization; 2013. - PubMed
    1. Wang Z, Kanguru L, Hussein J, Fitzmaurice A, Ritchie K. Incidence of adverse outcomes associated with gestational diabetes mellitus in low-and middle-income countries. Int J Gynecol Obstet. 2013;121(1):14–19. doi: 10.1016/j.ijgo.2012.10.032. - DOI - PubMed
    1. Roglic G. Diabetes in women: the global perspective. Int J Gynecol Obstet. 2009;104:S11–SS3. doi: 10.1016/j.ijgo.2008.11.022. - DOI - PubMed
    1. Casey BM, Lucas MJ, McIntire DD, Leveno KJ. Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population. Obstet Gynecol. 1997;90(6):869–873. doi: 10.1016/S0029-7844(97)00542-5. - DOI - PubMed
    1. Joffe GM, Esterlitz JR, Levine RJ, Clemens JD, Ewell MG, Sibai BM, et al. The relationship between abnormal glucose tolerance and hypertensive disorders of pregnancy in healthy nulliparous women. Am J Obstet Gynecol. 1998;179(4):1032–1037. doi: 10.1016/S0002-9378(98)70210-8. - DOI - PubMed