Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2020 Feb 3;20(1):43.
doi: 10.1186/s12886-020-1321-9.

The effect of adjunctive intravitreal conbercept at the end of diabetic vitrectomy for the prevention of post-vitrectomy hemorrhage in patients with severe proliferative diabetic retinopathy: a prospective, randomized pilot study

Tingting Jiang  1   2   3   4 , Junxiang Gu  1   2   3   4 , Peijun Zhang  1   2   3   4 , Wenwen Chen  1   2   3   4 , Qing Chang  5   6   7   8
Affiliations
Randomized Controlled Trial

The effect of adjunctive intravitreal conbercept at the end of diabetic vitrectomy for the prevention of post-vitrectomy hemorrhage in patients with severe proliferative diabetic retinopathy: a prospective, randomized pilot study

Tingting Jiang et al. BMC Ophthalmol. .

Abstract

Background: To investigate the effect of intravitreal conbercept (IVC) injections on the incidence of postoperative vitreous hemorrhage (VH) in eyes undergoing surgery for severe proliferative diabetic retinopathy.

Methods: This was a pilot prospective, comparative, and randomized study. Thirty patients, who underwent vitrectomy for severe proliferative diabetic retinopathy, were assigned randomly to either group 1 (intravitreal conbercept [IVC] injection at the end of pars plana vitrectomy) or group 2 (no IVC injection). Postoperative follow-up was performed on the first day, first week, first month, third month, sixth month and first year after surgery. The primary outcome was the incidence of postoperative VH. Secondary outcomes were the initial time of vitreous clearing (ITVC), best-corrected visual acuity (BCVA) and central retinal thickness (CRT) after surgery.

Results: A total of 30 eyes, from 30 patients, were included. Fifteen eyes were enrolled in the IVC group and fifteen in the control group. The incidence of early and late postoperative VH was not significantly different between the control and IVC groups. ITVC was shorter in the IVC group than that in the control group, but this was not significant (7.38 ± 10.66 vs 13.23 ± 17.35, P = 0.31). Final BCVA, 1 year after surgery, showed significant improvement compared to baseline in both groups. However, analysis of the BCVA at any postoperative visit after surgery showed no significant differences between the two groups. There were two cases of recurrent VH identified at 3 and 6 months after surgery in each group, requiring a second round of surgery. Foveal thickness was significantly different between the two groups at the 3-month, 6-month and 1-year follow-up visits.

Conclusions: In this pilot study, the effect of IVC injection in reducing the incidence of postoperative VH after diabetic vitrectomy at the end of vitrectomy was not shown.

Trial registration: The study was registered with the Chinese Clinical Trial Registry. (Reference Number: ChiCTR1800015751).

Keywords: Conbercept; Diabetic retinopathy; Macular edema; Vitrectomy; Vitreous hemorrhage.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The flow diagram of enrollment
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schachat AP, Oyakawa RT, Michels RG, Rice TA. Complications of vitreous surgery for diabetic retinopathy. II. Postoperative complications. Ophthalmology. 1983;90(5):522–530. doi: 10.1016/S0161-6420(83)34540-1. - DOI - PubMed
    1. de Bustros S, Glaser BM, Michels RG, Auer C. Effect of epsilon-aminocaproic acid on postvitrectomy haemorrhage. Arch Ophthalmol. 1985;103(2):219–221. doi: 10.1001/archopht.1985.01050020071023. - DOI - PubMed
    1. Ramezani AR, Ahmadieh H, Ghaseminejad AK, Yazdani S, Golestan B. Effect of tranexamic acid on early post-vitrectomy diabetic haemorrhage: a randomized clinical trial. Br J Ophthalmol. 2005;89(8):1041–1044. doi: 10.1136/bjo.2004.062638. - DOI - PMC - PubMed
    1. Joondeph BC, Blankenship GW. Haemostatic effects of air versus fluid in diabetic vitrectomy. Ophthalmol. 1989;96(12):1701–1706. doi: 10.1016/S0161-6420(89)32649-2. - DOI - PubMed
    1. Koutsandrea CN, Apostolopoulos MN, Chatzoulis DZ, Parikakis EA, Theodossiadis GP. Haemostatic effects of SF6 after diabetic vitrectomy for vitreous haemorrhage. Acta Ophthalmol Scand. 2001;79(1):34–38. doi: 10.1034/j.1600-0420.2001.079001034.x. - DOI - PubMed

Publication types

MeSH terms

Substances