Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Feb 4:9:e54665.
doi: 10.7554/eLife.54665.

Metabolism makes and mends the heart

Megan L Martik  1
Affiliations
Comment

Metabolism makes and mends the heart

Megan L Martik. Elife. .

Abstract

Experiments in zebrafish have shed new light on the relationship between development and regeneration in the heart.

Keywords: cardiomyocytes; developmental biology; heart development; metabolism; mouse; regeneration; zebrafish.

PubMed Disclaimer

Conflict of interest statement

MM No competing interests declared

Figures

Figure 1.
Figure 1.. Metabolic control of heart development and adult heart repair in the zebrafish.
(A) Trabeculae form in the heart when compact cardiomyocytes delaminate from the myocardium. Fukuda et al. found that Nrg1/ErbB2 signaling activates glycolysis to initiate the complex cell movements involved in delamination. (B) In the regenerating adult zebrafish heart, cardiomyocytes in the 'border zone' at the edge of the injured area de-differentiate and proliferate. Honkoop et al. uncovered a role for Nrg1/ErbB2 signaling in the control of metabolic reprogramming of the border zone cardiomyocytes from oxidative phosphorylation (OXPHOS) to glycolysis. Further, they found that glycolysis is required for proliferation after injury.
See this image and copyright information in PMC

Comment on

References

    1. D'Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, Weisinger K, Bassat E, Rajchman D, Yifa O, Lysenko M, Konfino T, Hegesh J, Brenner O, Neeman M, Yarden Y, Leor J, Sarig R, Harvey RP, Tzahor E. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nature Cell Biology. 2015;17:627–638. doi: 10.1038/ncb3149. - DOI - PubMed
    1. Fukuda R, Aharonov A, Ong YT, Stone OA, El-Brolosy M, Maischein H-M, Potente M, Tzahor E, Stainier DYR. Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. eLife. 2019;8:e50161. doi: 10.7554/eLife.50161. - DOI - PMC - PubMed
    1. Gemberling M, Karra R, Dickson AL, Poss KD. Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. eLife. 2015;4:e05871. doi: 10.7554/eLife.05871. - DOI - PMC - PubMed
    1. Honkoop H, de Bakker DEM, Aharonov A, Kruse F, Shakked A, Nguyen PD, de Heus C, Garric L, Muraro MJ, Shoffner A, Tessadori F, Peterson JC, Noort W, Bertozzi A, Weidinger G, Posthuma G, Grün D, van der Laarse WJ, Klumperman J, Jaspers RT, Poss KD, van Oudenaarden A, Tzahor E, Bakkers J. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLife. 2019;8:e50163. doi: 10.7554/eLife.50163. - DOI - PMC - PubMed
    1. Jopling C, Sleep E, Raya M, Martí M, Raya A, Izpisúa Belmonte JC. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 2010;464:606–609. doi: 10.1038/nature08899. - DOI - PMC - PubMed

Substances