Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer
- PMID: 32014912
- DOI: 10.21873/anticanres.14001
Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer
Erratum in
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Errata.Anticancer Res. 2020 Jul;40(7):4205. Anticancer Res. 2020. PMID: 32620672 No abstract available.
Abstract
Background/aim: Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. In contrast to localized disease, metastatic PCa leads to increased mortality. Kisspeptin (KISS1) functions as a metastasis suppressor in various cancers. The aim of this study was to detect the expression of KISS1 and its receptor GPR54 (KISS1R) in prostate cancer.
Materials and methods: The expression of KISS1 and KISS1R was examined in prostate cancer tissue specimens after radical prostatectomy.
Results: A higher expression of KISS1 and KISS1R was shown in patients with localized tumors (Stage ≤IIb) compared to patients with advanced (Stage ≥III) tumor. High Gleason score PCa and higher prognostic groups patients showed a lower expression rate of both KISS1 and KISS1R.
Conclusion: A down-regulation of KISS1-KISS1R system was detected in advanced prostate cancer. KISS1as tumor suppressor might be useful in the future for the diagnosis, risk assessment of prostate cancer progression, as well as a therapeutic target for aggressive tumors.
Keywords: KISS1; KISS1R; metastasis suppression; prostate cancer.
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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