Real Clinical Practice in ALK-rearranged NSCLC Patients: A Retrospective Observational Study

doi:10.21873/anticanres.14029

Observational Study

. 2020 Feb;40(2):957-964.

doi: 10.21873/anticanres.14029.

Real Clinical Practice in ALK-rearranged NSCLC Patients: A Retrospective Observational Study

Shinichiro Okauchi¹, Takeshi Numata², Takeshi Nawa³, Hideo Ichimura³, Takefumi Saito⁴, Kenji Hayashihara⁴, Hideyasu Yamada⁵, Hiroaki Satoh⁶, Takeshi Endo², Yoshihisa Inage², Takayuki Kaburagi⁷, Moriyuki Kiyoshima⁷, Yutaka Yamada⁷, Tomohiro Tamura⁷, Kazuhito Saito⁸, Masaharu Inagaki⁸, Nobuyuki Hizawa⁹, Yukio Sato⁹, Toshihiro Shiozawa⁹, Ikuo Sekine⁹, Hiroichi Ishikawa¹⁰, Koichi Kurihima¹⁰, Mitsuaki Sakai¹⁰, Koichi Kamiyama¹¹, Masaki Kimura¹¹, Norihiro Kikuchi¹², Hiroyuki Nakamura¹³, Kinya Furukawa¹³, Takahide Kodama¹⁴, Kunihiko Miyazaki¹⁴, Takaaki Yamashita¹⁵, Shigen Hayashi¹⁶, Yasunori Funayama¹⁷, Akihiro Nomura¹⁶

Affiliations

¹ Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan.
² Divisions of Respiratory Medicine and Thoracic Surgery, Mito Medical Center, Mito, Japan.
³ Divisions of Respiratory Medicine and Thoracic Surgery, Hitachi General Hospital, Hitachi, Japan.
⁴ Division of Respiratory Medicine, Ibarakihigashi Hospital, Tokai, Japan.
⁵ Division of Respiratory Medicine, Hitachinaka Medical Center, University of Tsukuba, Mito, Japan.
⁶ Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan hirosato@md.tsukuba.ac.jp.
⁷ Respiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Japan.
⁸ Divisions of Respiratory Medicine and Thoracic Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.
⁹ Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.
¹⁰ Divisions of Respiratory Medicine and Thoracic Surgery, Tsukuba Medical Center Hospital, Tsukuba, Japan.
¹¹ Division of Thoracic Surgery, Tsukuba Kinen Hospital, Tsukuba, Japan.
¹² Division of Respiratory Medicine, Kasumigaura Medical Center, Tsuchiura, Japan.
¹³ Divisions of Respiratory Medicine and Thoracic Surgery, Tokyo Medical University, Ibaraki Medical Center, Ami-machi, Japan.
¹⁴ Division of Respiratory Medicine, Ryugasaki Saiseikai Hospital, Ryugasaki, Japan.
¹⁵ Division of Respiratory Medicine, JA Toride Medical Center, Toride, Japan.
¹⁶ Division of Respiratory Medicine, Seinan Medical Center, Sakai-machi, Japan.
¹⁷ Division of Respiratory Medicine, Tsukuba Gakuen General Hospital, Tsukuba, Japan.

PMID: 32014940
DOI: 10.21873/anticanres.14029

Observational Study

Real Clinical Practice in ALK-rearranged NSCLC Patients: A Retrospective Observational Study

Shinichiro Okauchi et al. Anticancer Res. 2020 Feb.

. 2020 Feb;40(2):957-964.

doi: 10.21873/anticanres.14029.

Authors

Affiliations

¹ Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan.
² Divisions of Respiratory Medicine and Thoracic Surgery, Mito Medical Center, Mito, Japan.
³ Divisions of Respiratory Medicine and Thoracic Surgery, Hitachi General Hospital, Hitachi, Japan.
⁴ Division of Respiratory Medicine, Ibarakihigashi Hospital, Tokai, Japan.
⁵ Division of Respiratory Medicine, Hitachinaka Medical Center, University of Tsukuba, Mito, Japan.
⁶ Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan hirosato@md.tsukuba.ac.jp.
⁷ Respiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Japan.
⁸ Divisions of Respiratory Medicine and Thoracic Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.
⁹ Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.
¹⁰ Divisions of Respiratory Medicine and Thoracic Surgery, Tsukuba Medical Center Hospital, Tsukuba, Japan.
¹¹ Division of Thoracic Surgery, Tsukuba Kinen Hospital, Tsukuba, Japan.
¹² Division of Respiratory Medicine, Kasumigaura Medical Center, Tsuchiura, Japan.
¹³ Divisions of Respiratory Medicine and Thoracic Surgery, Tokyo Medical University, Ibaraki Medical Center, Ami-machi, Japan.
¹⁴ Division of Respiratory Medicine, Ryugasaki Saiseikai Hospital, Ryugasaki, Japan.
¹⁵ Division of Respiratory Medicine, JA Toride Medical Center, Toride, Japan.
¹⁶ Division of Respiratory Medicine, Seinan Medical Center, Sakai-machi, Japan.
¹⁷ Division of Respiratory Medicine, Tsukuba Gakuen General Hospital, Tsukuba, Japan.

PMID: 32014940
DOI: 10.21873/anticanres.14029

Abstract

Background/aim: To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation.

Patients and methods: We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institutes that cover a population of three million people.

Results: There were 129 ALK rearranged NSCLC patients. Among them, 103 patients including 40 recurrent disease cases received ALK-tyrosine kinase inhibitors (TKI) and chemotherapy. Our treatment results were comparable to previously reported clinical trials and clinical practice studies. First-line alectinib, treatment sequence of ALK-TKI followed by another ALK-TKI, and pemetrexed-containing chemotherapy contributed to the outcome of treatment.

Conclusion: By arrangement of treatment such as treatment sequence of ALK-TKI and chemotherapy regimen, it might be possible to obtain a treatment outcome almost equivalent to those of clinical trials even in real clinical practice.

Keywords: Clinical practice; alectinib; anaplastic lymphoma kinase fusion gene mutation; chemotherapy; non-small cell lung cancer.

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Real Clinical Practice in ALK-rearranged NSCLC Patients: A Retrospective Observational Study

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Real Clinical Practice in ALK-rearranged NSCLC Patients: A Retrospective Observational Study

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