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Review
. 2020 Apr;91(4):411-417.
doi: 10.1136/jnnp-2019-322424. Epub 2020 Feb 3.

Ischaemic stroke in young adults: a global perspective

Esther Boot #  1 , Merel Sanne Ekker #  1 , Jukka Putaala  2 , Steven Kittner  3 , Frank-Erik De Leeuw  1 , Anil M Tuladhar  4
Affiliations
Review

Ischaemic stroke in young adults: a global perspective

Esther Boot et al. J Neurol Neurosurg Psychiatry. 2020 Apr.

Abstract

Ischaemic stroke at young age is an increasing problem in both developing and developed countries due to rising incidence, high morbidity and mortality and long-term psychological, physical and social consequences. Compared with stroke in older adults, stroke in young adults is more heterogeneous due to the wide variety of possible underlying risk factors and aetiologies. In this review, we will provide an overview of the global variation in the epidemiology of stroke in young adults, with special attention to differences in geography, ethnicity/race and sex, as well as traditional and novel risk factors for early-onset ischaemic stroke, such as air pollution. Understanding global differences is an important prerequisite for better region-specific prevention and treatment of this devastating condition.

Keywords: clinical neurology; epidemiology; stroke.

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Conflict of interest statement

Competing interests: AMT is a junior staff member of the Dutch Heart Foundation, project title: “life after ischaemic stroke in young adults” (grant number 2016T044). F-EDL has received the Innovational Research Incentive grant (016-126-351) and the Clinical established investigator Dutch Heart Foundation grant (2014T060). JP has received funding for research on stroke in the young from the Academy of Finland (318075) and Helsinki and Uusimaa Hospital District (TYH2018318). SK effort on this project was partly supported by VA RR&D N1699-R and NINDS R01NS100178 and R01NS105150.

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