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. 1988;10(4):499-500.
doi: 10.1097/00007691-198804000-00022.

Clinical response and total and unbound plasma concentrations after lidocaine overdose

D K Armstrong  1 , D L Bremseth, J J Lima
Affiliations

Clinical response and total and unbound plasma concentrations after lidocaine overdose

D K Armstrong et al. Ther Drug Monit. 1988.

Abstract

Plasma and unbound concentrations and hemodynamic and CNS effects were monitored in a patient after overdose of 2 g of lidocaine HCl infused during 1 h. Hypotension, decreased heart rate, tremors, and nonresponsiveness to stimuli were observed at plasma and unbound concentrations of 17.7 and 12.0 micrograms/ml. The half-lives of decline of plasma and unbound concentrations were 3.8 and 2.7 h; the difference in half-lives was due to nonlinear plasma protein binding.

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