The evolving treatment paradigm for BRAF V600 mutant colorectal cancer
- PMID: 32015976
- PMCID: PMC6976492
- DOI: 10.21037/atm.2019.12.61
The evolving treatment paradigm for BRAF V600 mutant colorectal cancer
Conflict of interest statement
Conflicts of Interest: Dr. Kratz has no conflicts of interest to declare. Dr. Deming has served on an advisory board for Array BioPharma.
Comment on
-
Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study.J Clin Oncol. 2019 Jun 10;37(17):1460-1469. doi: 10.1200/JCO.18.02459. Epub 2019 Mar 20. J Clin Oncol. 2019. PMID: 30892987 Free PMC article. Clinical Trial.
References
-
- Innocenti F, Ou FS, Zemla T, et al. Somatic DNA mutations, MSI status, mutational load (ML): Association with overall survival (OS) in patients (pts) with metastatic colorectal cancer (mCRC) of CALGB/SWOG 80405 (Alliance). American Society of Clinical Oncology, 2017.
-
- Cremolini C, Loupakis F, Antoniotti C, et al. FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study. Lancet Oncol 2015;16:1306-15. 10.1016/S1470-2045(15)00122-9 - DOI - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials