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Editorial
. 2019 Dec;7(Suppl 8):S262.
doi: 10.21037/atm.2019.12.32.

Tumor modeling maintains diverse pathology in vitro

Michael E Bregenzer  1 , Eric N Horst  1 , Pooja Mehta  2 , Caymen M Novak  1 , Taylor Repetto  2 , Catherine S Snyder  2 , Geeta Mehta  1   2   3   4   5
Affiliations
Editorial

Tumor modeling maintains diverse pathology in vitro

Michael E Bregenzer et al. Ann Transl Med. 2019 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Establishing ovarian cancer biobanks using organoids. (A) Kopper et al. extracted tissue from human ovarian cancer. Primary and secondary tumors were collected from several locations followed by in vitro 3D culturing and genomic analysis. (B) These patient samples were cultured in a new organoid culture-based platform developed by Kopper et al. in order to carry out several characterization techniques to identify origin and phenotype of the collected patient samples. This system and subsequent analysis could be used to address clinical challenges of early detection, tumor heterogeneity, recurrence and development of chemoresistance. (C) Using the developed culture platform, Kopper et al. was able to isolate 56 different cell lines to form a biobank from which other researchers could conduct further studies of ovarian cancer. Numbers on the pie chart indicate number of patient lines created for each histotype. CCC, clear cell carcinoma; END, endometrioid; SBT, serous borderline tumor; MC, malignant mucinous; MBT, mucinous borderline tumor; LGS, low grade serous; HGS, high grade serous.
See this image and copyright information in PMC

Comment on

  • An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
    Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H. Kopper O, et al. Nat Med. 2019 May;25(5):838-849. doi: 10.1038/s41591-019-0422-6. Epub 2019 Apr 22. Nat Med. 2019. PMID: 31011202

References

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