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Editorial
. 2019 Dec;7(Suppl 8):S282.
doi: 10.21037/atm.2019.12.31.

Elderly patients and PD-L1-positive advanced non-small cell lung cancer: is pembrolizumab monotherapy effective and safe?

Cesare Gridelli  1 , Assunta Sgambato  1
Affiliations
Editorial

Elderly patients and PD-L1-positive advanced non-small cell lung cancer: is pembrolizumab monotherapy effective and safe?

Cesare Gridelli et al. Ann Transl Med. 2019 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: Gridelli C: honoraria as advisory board or speaker bureau member for Astra Zeneca, BMS, MSD, Roche. The other author has no conflicts of interest to declare.

Comment on

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019;69:7-34. 10.3322/caac.21551 - DOI - PubMed
    1. Garon EB, Hellmann MD, Rizvi NA, et al. Five-Year Overall Survival for Patients With Advanced Non-Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study. J Clin Oncol 2019;37:2518-27. 10.1200/JCO.19.00934 - DOI - PMC - PubMed
    1. Denson AC, Mahipal A. Participation of the elderly population in clinical trials: barriers and solutions. Cancer Control 2014;21:209-14. 10.1177/107327481402100305 - DOI - PubMed
    1. Elias R, Giobbie-Hurder A, Rahma OE. Efficacy of PD-1 and PD-L1 inhibitors in older adults: a meta-analysis. J Clin Oncol 2017;35:abstr e21544. - PMC - PubMed
    1. Marur S, Singh H, Mishra-Kalyani P, et al. FDA analyses of survival in older adults with metastatic non-small cell lung cancer in controlled trials of PD-1/PD-L1 blocking antibodies. Semin Oncol 2018;45:220-5. 10.1053/j.seminoncol.2018.08.007 - DOI - PubMed