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Editorial
. 2019 Dec;7(Suppl 8):S284.
doi: 10.21037/atm.2019.11.119.

Brake adjustment: Ca2+ entry pathway provides a novel target for acute pancreatitis therapy

Richard T Waldron  1 , Aurelia Lugea  1 , Stephen J Pandol  1
Affiliations
Editorial

Brake adjustment: Ca2+ entry pathway provides a novel target for acute pancreatitis therapy

Richard T Waldron et al. Ann Transl Med. 2019 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
SOCE switched on by STIM-mediated gating of Orai channels, and the aftermath of OFF-switching. (I) Upon sensing a reduced Ca2+ level within the ER lumen, STIMs cluster and couple to Orai channels to activate SOCE (left); (II) the regulator SARAF binds to STIM and acts as a “brake” on SOCE (right). SOCE, store-operated Ca2+ entry; STIM, stromal interaction molecule; ER, endoplasmic reticulum; SARAF, SOCE-associated regulatory factor.
See this image and copyright information in PMC

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