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Editorial
. 2019 Dec;7(Suppl 8):S306.
doi: 10.21037/atm.2019.10.72.

Glycosylation alterations in acute pancreatitis and pancreatic cancer: CA19-9 expression is involved in pathogenesis and maybe targeted by therapy

Ionut Negoi  1   2 , Mircea Beuran  1   2 , Sorin Hostiuc  1   3 , Massimo Sartelli  4 , Alaa El-Hussuna  5 , Enrique de-Madaria  6
Affiliations
Editorial

Glycosylation alterations in acute pancreatitis and pancreatic cancer: CA19-9 expression is involved in pathogenesis and maybe targeted by therapy

Ionut Negoi et al. Ann Transl Med. 2019 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Text analysis of the title and abstracts of papers retrieved in the Web of Science database, using the search strategy from Table 1, using the VOSviewer software. Maybe observed important inter-relations between ‘CA 19-9’ ‘expression’, primary ‘tumor’, ‘borderline’ and ‘metastatic’ tumors as words in the abstracts of the retrieved papers.
Figure S1
Figure S1
Mouse model comparison for pancreatitis. (A) H&E, (B) Masson’s Trichrome (MT), and (C) CA19-9 IHC of mouse pancreata from genetically negative control littermates and R;F, mice treated with Dox. Closed arrows indicate ducts and open arrows indicate islets. eGFP IHC on untreated and 7-day Dox-treated (D) R;F and (E) C;RLSL;F mouse pancreata, duodenum, and gall bladder. Closed arrows indicate positive islet cells, open arrows indicate positive ducts, * indicates negative vessels and “a” indicates positive acinar cells. CA19-9 IHC on untreated and 28-day Dox treated (F) R;F and (G) C;RLSL;F mouse duodenum and gallbladder. Scale bars =50 µm [From ref (1)].
See this image and copyright information in PMC

Comment on

  • The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
    Engle DD, Tiriac H, Rivera KD, Pommier A, Whalen S, Oni TE, Alagesan B, Lee EJ, Yao MA, Lucito MS, Spielman B, Da Silva B, Schoepfer C, Wright K, Creighton B, Afinowicz L, Yu KH, Grützmann R, Aust D, Gimotty PA, Pollard KS, Hruban RH, Goggins MG, Pilarsky C, Park Y, Pappin DJ, Hollingsworth MA, Tuveson DA. Engle DD, et al. Science. 2019 Jun 21;364(6446):1156-1162. doi: 10.1126/science.aaw3145. Science. 2019. PMID: 31221853 Free PMC article.

References

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