Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Dec;7(Suppl 8):S338.
doi: 10.21037/atm.2019.09.100.

More than just a screen to liberate from mechanical ventilation: treat to keep extubated?

Jie Li  1 , J Brady Scott  1 , Jun Duan  2 , Kai Liu  3 , James B Fink  1   4
Affiliations
Editorial

More than just a screen to liberate from mechanical ventilation: treat to keep extubated?

Jie Li et al. Ann Transl Med. 2019 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: Dr. Fink is Chief Science Officer for Aerogen Pharma Corp and discloses relationships with Dance Biopharm. Mr. Scott discloses relationship with Ventec Life Systems. The other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
In the Subirà et al.’s study, among the 575 patients who were assigned to receive 30 min PSV SBT, 532 patients passed SBT and were extubated. The remaining 43 patients failed SBT, however 9 were still extubated. In those 541 extubated patients, 51 of them received prophylactic NIV and 91 received prophylactic HFNC. The exact number of patients who received prophylactic NIV and HFNC were unknown in the 532 patients who passed the SBT and were extubated. One hundred and ten in 532 patients developed post-extubation respiratory failure, but the number of patients in the groups of COT, prophylactic NIV and HFNC were unreported. For those 110 patients, some might have changed respiratory support devices, such as from COT to HFNC or NIV, or from HFNC to NIV, as a “rescue therapy”, 59 patients ended with reintubation. The number of patients in those rescue treatment groups were unknown. Similar situation also exists in the group of 2-hour T-piece SBT. NIV, noninvasive ventilation; HFNC, high-flow nasal cannula; COT, conventional oxygen therapy.
See this image and copyright information in PMC

Comment on

References

    1. Wolkewitz M, Palomar-Martinez M, Alvarez-Lerma F, et al. Analyzing the impact of duration of ventilation, hospitalization, and ventilation episodes on the risk of pneumonia. Infect Control Hosp Epidemiol 2019;40:301-6. 10.1017/ice.2018.360 - DOI - PubMed
    1. Petrof BJ. Diaphragm weakness in the critically ill: Basic mechanisms reveal therapeutic opportunities. Chest 2018;154:1395-403. 10.1016/j.chest.2018.08.1028 - DOI - PubMed
    1. Kallet RH. Ventilator bundles in transition: From prevention of ventilator-associated pneumonia to prevention of ventilator-associated events. Respir Care 2019;64:994-1006. 10.4187/respcare.06966 - DOI - PubMed
    1. Esteban A, Alía I, Gordo F, et al. Extubation outcome after spontaneous breathing trials with T-tube or pressure support ventilation. Am J Respir Crit Care Med 1997;156:459-65. 10.1164/ajrccm.156.2.9610109 - DOI - PubMed
    1. Esteban A, Alía I, Tobin MJ, et al. Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Am J Respir Crit Care Med 1999;159:512-8. 10.1164/ajrccm.159.2.9803106 - DOI - PubMed