Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Dec;7(Suppl 8):S352.
doi: 10.21037/atm.2019.09.71.

Standard of usual care defines effectiveness of early goal directed therapy

Vikram Mukherjee  1 , Jan Bakker  1   2   3   4
Affiliations
Editorial

Standard of usual care defines effectiveness of early goal directed therapy

Vikram Mukherjee et al. Ann Transl Med. 2019 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Variations in mortality rates in the usual care arms of randomized controlled trials comparing usual care to early goal directed therapy in patients with severe sepsis or septic shock [the results of the study by Rivers et al. (3) has been left out of this figure as this is seen as the landmark study].
See this image and copyright information in PMC

Comment on

References

    1. Adhikari NK, Fowler RA, Bhagwanjee S, et al. Critical care and the global burden of critical illness in adults. Lancet 2010;376:1339-46. 10.1016/S0140-6736(10)60446-1 - DOI - PMC - PubMed
    1. Sakr Y, Jaschinski U, Wittebole X, et al. Sepsis in Intensive Care Unit Patients: Worldwide Data From the Intensive Care over Nations Audit. Open Forum Infect Dis 2018;5:ofy313. - PMC - PubMed
    1. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77. 10.1056/NEJMoa010307 - DOI - PubMed
    1. Ding XF, Yang ZY, Xu ZT, et al. Early goal-directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials. J Transl Med 2018;16:331. 10.1186/s12967-018-1700-7 - DOI - PMC - PubMed
    1. ARISE Investigators, ANZICS Clinical Trials Group , Peake SL, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014;371:1496-506. 10.1056/NEJMoa1404380 - DOI - PubMed