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Review
. 2020 Feb 3;37(3):45.
doi: 10.1007/s11095-020-2763-8.

Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects

Christian Schöneich  1
Affiliations
Review

Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects

Christian Schöneich. Pharm Res. .

Abstract

Therapeutic proteins are sensitive to photo-degradation by UV A and visible light. As none of the essential amino acids exhibits significant absorption in the UV A and visible light regions, the underlying mechanisms of photo-degradation induced by UV A and visible light are not well understood. This review addresses potential mechanisms, by which protein structure, oxidative modifications or impurities can promote the photo-degradation of therapeutic proteins during the exposure to UV A and visible light.

Keywords: histidine; photostability; protein oxidation; radicals; reaction mechanisms; tryptophan; tyrosine.

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