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. 2020 Aug;36(3):269-276.
doi: 10.1007/s12550-020-00387-8. Epub 2020 Feb 3.

Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China

Kai Fan #  1   2 , Xi Cheng #  1 , Wenbo Guo  2 , Xing Liu  2 , Zhiqi Zhang  2 , Qi Yao  3 , Dongxie Nie  2 , Bing Yao  4 , Zheng Han  5
Affiliations

Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China

Kai Fan et al. Mycotoxin Res. 2020 Aug.

Abstract

This study was conducted to investigate the exposure to ochratoxin A (OTA) of populations living in Nanjing, China. Plasma samples were collected from 147 healthy adults (age 18-63 years) and analyzed for OTA by a reliable and sensitive ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method (limit of detection 0.04 ng/mL). After enzymatic hydrolysis by β-glucuronidase/arylsulfatase, OTA was detected in 80.9% plasma samples with mean concentration of 0.26 ± 0.59 ng/mL (range 0.04-6.59 ng/mL). The estimated daily intakes of OTA based on plasma concentrations (mean 0.51 ng/kg bw/day, max 12.99 ng/kg bw/day) were lower than the tolerable daily intake published by European Food Safety Authority (EFSA) or Joint FAO/WHO Expert Committee on Food Additives (JFECFA) indicative of rare risks related to the OTA exposure in the investigated area. This study provides a valuable insight on human exposure to OTA in China. Further studies in children and elder people and in adult cohorts from other regions are recommended.

Keywords: Biomarker; Exposure assessment; Ochratoxin A; Plasma.

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