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. 2020 Feb;72(1):13-23.
doi: 10.1007/s43440-019-00024-x. Epub 2020 Jan 8.

Baicalin and its aglycone: a novel approach for treatment of metabolic disorders

Penghua Fang  1   2 , Mei Yu  1 , Mingyi Shi  2 , Ping Bo  3   2 , Xuewen Gu  4 , Zhenwen Zhang  5
Affiliations

Baicalin and its aglycone: a novel approach for treatment of metabolic disorders

Penghua Fang et al. Pharmacol Rep. 2020 Feb.

Abstract

Background: The current strategies for prevention and treatment of insulin resistance and type 2 diabetes are not fully effective and frequently accompanied by many negative effects. Therefore, novel ways to prevent insulin resistance and type 2 diabetes are urgently needed. The roots of Scutellaria radix are commonly used in traditional Chinese medicines for prevention and treatment of type 2 diabetes, atherosclerosis, hypertension, hyperlipidemia, dysentery, and other respiratory disorders. Baicalin and baicalein are the major and active ingredient extracts from Scutellaria baicalensis.

Methods: A comprehensive and systematic review of literature on baicalin and baicalein was carried out.

Results: Emerging evidence indicated that baicalin and baicalein possessed hepatoprotective, anti-oxidative, anti-dyslipidemic, anti-lipogenic, anti-obese, anti-inflammatory, and anti-diabetic effects, being effective for treating obesity, insulin resistance, non-alcoholic fatty liver, and dyslipidemia. Besides, baicalin and baicalein are almost non-toxic to epithelial, peripheral, and myeloid cells.

Conclusion: The purpose of this study is to focus on the therapeutic applications and accompanying molecular mechanisms of baicalin and baicalein against hyperglycemia, insulin resistance, type 2 diabetes, hyperlipidemia, obesity, and non-alcoholic fatty liver, and trying to establish a novel anti-obese and anti-diabetic strategy.

Keywords: Baicalein; Baicalin; Diabetes; Insulin resistance; Obesity.

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