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. 2020 Feb:31 Suppl 24:13-15.
doi: 10.1111/pai.13158.

Macrophage activation syndrome in pediatrics

Alessandra Alongi  1 , Roberta Naddei  2 , Laura De Miglio  3 , Valentina Natoli  1 , Angelo Ravelli  1   4   5
Affiliations

Macrophage activation syndrome in pediatrics

Alessandra Alongi et al. Pediatr Allergy Immunol. 2020 Feb.

Abstract

Macrophage activation syndrome (MAS) is a serious, potentially life-threatening, hyperinflammatory condition, which belongs to the spectrum of hemophagocytic lymphohistiocytosis (HLH) and can complicate several immunologic and rheumatic disorders. MAS is characterized by a dysfunctional immune response that is similar to that seen in other forms of HLH. Because MAS may pursue a rapidly fatal course, prompt recognition of its clinical and laboratory features and immediate therapeutic intervention are fundamental. Recently, a set of classification criteria for MAS complicating sJIA has been developed through a multinational collaborative effort. High-dose parenteral corticosteroids remain the mainstay of treatment of MAS.

Keywords: activation; inflammation; macrophage.

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References

REFERENCES

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