Cell Biology: Function Guides Form of Auditory Sensory Cells
- PMID: 32017884
- DOI: 10.1016/j.cub.2019.12.039
Cell Biology: Function Guides Form of Auditory Sensory Cells
Abstract
Mechanosensory bundles on auditory sensory cells are composed of stereocilia that grow in rows of decreasing height. This pattern depends on the specification of the eventual tallest row, then the assignment of distinct molecular identities to the shorter rows. Mechanotransduction refines and maintains row identity, thus instructing the form of the bundle.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair Bundle Row Identity.Curr Biol. 2019 Mar 18;29(6):921-934.e4. doi: 10.1016/j.cub.2019.01.051. Epub 2019 Feb 28. Curr Biol. 2019. PMID: 30827920 Free PMC article.
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Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells.Curr Biol. 2020 Feb 3;30(3):442-454.e7. doi: 10.1016/j.cub.2019.11.076. Epub 2020 Jan 2. Curr Biol. 2020. PMID: 31902726 Free PMC article.
