Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

Andrea Genazzani¹, Nick Panay², Tommaso Simoncini³, Herman Depypere⁴, Alfred Mueck^{5

6}, Christian Egarter⁷, Nicoletta Biglia⁸, Tomas Fait⁹, Martin Birkhaeuser¹⁰, Sven O Skouby¹¹, Mark Brincat¹², Steven Goldstein¹³, Xiangyan Ruan^{5

6}, Cuauhtémoc Celis-Gonzales¹⁴, Santiago Palacios¹⁵

Affiliations

¹ Department of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.
² Queen Charlotte's & Chelsea and Westminster Hospitals and Imperial College, London, The International Menopause Society, London, UK.
³ Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
⁴ Breast Clinic and Menopause Clinic, University Hospital, Gent, Belgium.
⁵ Department of Women's Health, University Hospitals of Tuebingen, Tuebingen, Germany.
⁶ Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
⁷ Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna, Vienna, Austria.
⁸ Academic Division of Gynecology and Obstetrics, Mauriziano Hospital, University of Turin, Turin, Italy.
⁹ Department of Obstetrics and Gynecology, Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
¹⁰ Department Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Bern, Bern, Switzerland.
¹¹ Department of Gynecology and Obstetrics, Herlev University Hospital, Copenhagen, Denmark.
¹² Department of Obstetrics & Gynecology, Mater Dei Hospital, Msida, Malta.
¹³ New York University School of Medicine, New York, NY, USA.
¹⁴ Federación Mexicana de Colegios de Ginecología y Obstetricia (FEMECOG), Mexico, Mexico.
¹⁵ Palacios Institute of Women's Health, Madrid, Spain.

PMID: 32019391
DOI: 10.1080/09513590.2020.1722994

Free article

Review

Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

Andrea Genazzani et al. Gynecol Endocrinol. 2020 Mar.

Free article

. 2020 Mar;36(3):190-196.

doi: 10.1080/09513590.2020.1722994. Epub 2020 Feb 5.

Authors

Affiliations

¹ Department of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.
² Queen Charlotte's & Chelsea and Westminster Hospitals and Imperial College, London, The International Menopause Society, London, UK.
³ Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
⁴ Breast Clinic and Menopause Clinic, University Hospital, Gent, Belgium.
⁵ Department of Women's Health, University Hospitals of Tuebingen, Tuebingen, Germany.
⁶ Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
⁷ Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna, Vienna, Austria.
⁸ Academic Division of Gynecology and Obstetrics, Mauriziano Hospital, University of Turin, Turin, Italy.
⁹ Department of Obstetrics and Gynecology, Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
¹⁰ Department Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Bern, Bern, Switzerland.
¹¹ Department of Gynecology and Obstetrics, Herlev University Hospital, Copenhagen, Denmark.
¹² Department of Obstetrics & Gynecology, Mater Dei Hospital, Msida, Malta.
¹³ New York University School of Medicine, New York, NY, USA.
¹⁴ Federación Mexicana de Colegios de Ginecología y Obstetricia (FEMECOG), Mexico, Mexico.
¹⁵ Palacios Institute of Women's Health, Madrid, Spain.

PMID: 32019391
DOI: 10.1080/09513590.2020.1722994

Abstract

Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin^®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin^® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin^®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin^® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.

Keywords: PureCyTonin®; Purified and specific cytoplasmic pollen extract; Serelys®; hot flushes; menopause; non-hormonal alternative; premenstrual syndrome.

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Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

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Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

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