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. 2020 Feb 28;38(10):2292-2297.
doi: 10.1016/j.vaccine.2020.01.075. Epub 2020 Feb 1.

Application of a cost-effectiveness analysis of pathogen-specific vaccines against gastroenteritis to a military population in a developing country setting

Sarah-Blythe Ballard  1 , Aaron Tallant  2 , Rosio G Guerra  3 , Dawn Quigley  4 , Regan Stiegmann  5 , Andrew J Mirelman  6 , Mark S Riddle  7 , Robert H Gilman  8 ; Norovirus Working Group in Peru
Affiliations

Application of a cost-effectiveness analysis of pathogen-specific vaccines against gastroenteritis to a military population in a developing country setting

Sarah-Blythe Ballard et al. Vaccine. .

Abstract

Vaccine implementation planning in low- and middle-income countries (LMIC) often focuses on children without considering special adult populations. We adapted an economic model developed by the United States Department of Defense (DoD) to evaluate the cost-effectiveness of vaccine acquisition strategies for Campylobacter-, ETEC-, Shigella-, and norovirus-associated gastroenteritis. We compared implementation costs with current medical management in the Peruvian armed forces, a special population of low- and middle-income (LMIC) adults with a high incidence of infectious gastroenteritis. Pathogen-specific vaccine implementation resulted in calculated cost-effectiveness ratio (CER) per duty day lost averted (CERDDL) of $13,741; $1,272; $301; and $803, and a CER per diarrhea day averted of $2,130; $215; $51; and $199 for Campylobacter, ETEC, Shigella, and norovirus, respectively. These estimates compare favorably to CERDDL estimates from high-income military population and suggest that implementing vaccines gastroenteritis may be cost-effective in the Peruvian military population.

Keywords: Cost-effectiveness analysis; Gastroenteritis; Low- and middle-income countries; Military; Peru; Vaccine.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1.
Fig. 1.
Tornado analyses for (A) Campylobacter; (B) ETEC; (C) Shigella; and (D) norovirus vaccine cost-effectiveness ratios demonstrating top ten parameters influencing the cost-effectiveness ratio per duty day lost averted outcome in the model.
Fig. 1.
Fig. 1.
Tornado analyses for (A) Campylobacter; (B) ETEC; (C) Shigella; and (D) norovirus vaccine cost-effectiveness ratios demonstrating top ten parameters influencing the cost-effectiveness ratio per duty day lost averted outcome in the model.
See this image and copyright information in PMC

References

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