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. 2019 Nov 27:19:9-13.
doi: 10.1016/j.jor.2019.11.034. eCollection 2020 May-Jun.

Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations

Makrina Karaglani  1 , Evmorfia Tzitzikou  1 , Stylianos Tottas  2 , Ioannis Kougioumtzis  2 , Konstantinos Arvanitidis  1 , George Kolios  1 , Ekaterini Chatzaki  1 , Georgios I Drosos  2
Affiliations

Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations

Makrina Karaglani et al. J Orthop. .

Abstract

Polymethylmethacrylate (PMMA) represents the current gold standard as an antibiotic delivery carrier in orthopaedic surgery. Despite the accepted use of local antibiotic carriers, there aren't any conclusive data comparing PMMA to Bone Graft Substitutes. The aim of this in vitro study was to compare the elution profile of gentamicin from various preparations of PMMA cements and Herafill beads. All cements had high initial elution during the first hour which then slowly decreased, Herafill beads on the other hand showed its higher elution around the eighth hour. Herafill, in general, presented the highest elution of gentamicin regardless of its input amount.

Keywords: Copal; Gentamicin; Herafill; In vitro release; PMMA; Palacos.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
The elution profile of gentamicin from Herafill and all PMMA specimens for 288 h.
Fig. 2
Fig. 2
A) The elution profile of gentamicin from Herafill and home-made Palacos R + G both containing 1% gentamicin for 288 h. B) The elution profile of gentamicin from Palacos R + G and home-made Palacos R + G both containing 1.2% gentamicin for 288 h. C) The elution profile of gentamicin from Copal G + V and home-made Palacos R + G + V both containing 1.2% gentamicin and 5% vancomycin for 288 h. D) The elution profile of gentamicin from Copal G + C and home-made Palacos R + G both containing 2.4% gentamicin for 288 h * indicates statistically significant difference.
See this image and copyright information in PMC

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