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Review
. 2020 Jan 13:14:89-94.
doi: 10.2147/OPTH.S238756. eCollection 2020.

Dexamethasone 0.4mg Sustained-Release Intracanalicular Insert in the Management of Ocular Inflammation and Pain Following Ophthalmic Surgery: Design, Development and Place in Therapy

Cassandra C Brooks  1 , Sayena Jabbehdari  1   2 , Preeya K Gupta  1
Affiliations
Review

Dexamethasone 0.4mg Sustained-Release Intracanalicular Insert in the Management of Ocular Inflammation and Pain Following Ophthalmic Surgery: Design, Development and Place in Therapy

Cassandra C Brooks et al. Clin Ophthalmol. .

Abstract

Inflammation and pain are two prevalent findings after ocular surgery. Corticosteroids are widely administrated as a core treatment to control post-surgical inflammation and pain. Improper patient adherence to post-operative eye drop regimens, limited bioavailability of topical eye drops, and the negative impact of preservatives used in many of these eye drops, has made a strong case for novel therapies in the treatment of post-operative pain and inflammation. This review of the literature will focus on the role of intracanalicular sustained-release dexamethasone (Dextenza, Ocular Therapeutix, Bedford, MA, USA) for the management of ocular inflammation and pain.

Keywords: dexamethasone; intracanalicular; ocular inflammation; ocular pain; ophthalmic surgery; sustained-release.

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Conflict of interest statement

Dr Preeya K Gupta is consultant for Alcon, Eyepoint, Allergan, Johnson & Johnson Vision, and Ocular Science, outside the submitted work. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Sustained-release dexamethasone intracanalicular insert. Images courtesy of Ocular Therapeutix, Inc.
See this image and copyright information in PMC

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