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Case Reports
. 2020 Jan 25;6(2):139-140.
doi: 10.1016/j.jdcr.2019.12.002. eCollection 2020 Feb.

Alcohol-induced facial flushing in a patient with atopic dermatitis treated with dupilumab

Sean J Igelman  1 , Chanho Na  2 , Eric L Simpson  3
Affiliations
Case Reports

Alcohol-induced facial flushing in a patient with atopic dermatitis treated with dupilumab

Sean J Igelman et al. JAAD Case Rep. .
No abstract available

Keywords: AD, atopic dermatitis; ALDH2, aldehyde dehydrogenase 2; CYP2E1, cytochrome P450 2E1; CYP450, cytochrome P450; alcohol; atopic dermatitis; dupilumab; eczema; facial flushing.

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Figures

Fig 1
Fig 1
A and B, Distinct periorbital and perioral erythema after alcohol consumption while on dupilumab therapy and tacrolimus ointment.
See this image and copyright information in PMC

References

    1. Simpson E.L., Bieber T., Guttman-Yassky E. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med. 2016;375:2335–2348. - PubMed
    1. Herz S., Petri M., Sondermann W. New alcohol flushing in a patient with atopic dermatitis under therapy with dupilumab. Dermatol Ther. 2019;32:e12762. - PubMed
    1. Lafont E., Sokol H., Sarre-Annweiler M.E. Causes and differential diagnosis of flush. Rev Med Interne. 2014;35(5):303–309. - PubMed
    1. Dupixent (dupilumab) [package insert] Regeneron Pharmaceuticals Inc; Tarrytown, NY: 2017.
    1. Peter Guengerich F., Avadhani N.G. Roles of cytochrome P450 in metabolism of ethanol and carcinogens. Adv Exp Med Biol. 2018;1032:15–35. - PMC - PubMed

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