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. 2020 Jan 25;5(1):19-20.
doi: 10.1016/j.synbio.2020.01.005. eCollection 2020 Mar.

The X-factor: Enhanced β-oxidation on intracellular triacylglycerols enabling overproduction of polyketide drug-like molecules in microorganisms

Shan Wang  1 , Hai Deng  1
Affiliations

The X-factor: Enhanced β-oxidation on intracellular triacylglycerols enabling overproduction of polyketide drug-like molecules in microorganisms

Shan Wang et al. Synth Syst Biotechnol. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] Synth Syst Biotechnol. 2020 Oct 14;5(4):330-331. doi: 10.1016/j.synbio.2020.10.001. eCollection 2020 Dec. Synth Syst Biotechnol. 2020. PMID: 33102827 Free PMC article.
No abstract available

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Figures

Fig. 1
Fig. 1
β-Oxidation up-regulation strategy on intracellular triacylglycerols (TAGs) employed in Ref. [8]. Intracellular TAGs which accumulate in primary metabolism are mobilized to produce polyketides via β-oxidation during stationary phase. Overexpression of the fatty acyl-CoA synthetase (ACS) allows overproduction of acyl-CoA to enter β-oxidation cycle, and therefore increasing the cellular level of acetyl-CoA, the key precursor of polyketides, as well as reducing equivalents and ATP. The high level of the latter two metabolites further inhibit TCA cycles, which in turn weakens the carbon flux from acetyl-CoA to TCA cycle but increases the precursor supply towards polyketide biosynthesis.
See this image and copyright information in PMC

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