Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Apr 15;16(4):643.
doi: 10.5664/jcsm.8296.

Alpha-1 adrenergic antagonists use increases the risk of sleep apnea: implications for understanding the role of prazosin in posttraumatic stress syndrome

William V McCall  1
Affiliations
Comment

Alpha-1 adrenergic antagonists use increases the risk of sleep apnea: implications for understanding the role of prazosin in posttraumatic stress syndrome

William V McCall. J Clin Sleep Med. .

Abstract

McCall WV. Alpha-1 adrenergic antagonists use increases the risk of sleep apnea: implications for understanding the role of prazosin in posttraumatic stress syndrome. J Clin Sleep Med. 2020;16(4):643.

PubMed Disclaimer

Comment in

  • Author response.
    Su PL, Lin CY, Lin SH. Su PL, et al. J Clin Sleep Med. 2020 Apr 15;16(4):645-646. doi: 10.5664/jcsm.8298. J Clin Sleep Med. 2020. PMID: 32022676 Free PMC article.

Comment on

References

    1. Su P-L, Lin W-K, Lin C-Y, et al. Alpha-1 adrenergic-antagonist use increases the risk of sleep apnea: a nationwide population-based cohort study. J Clin Sleep Med. 2019;15(11):1571–1579. - PMC - PubMed
    1. George K, Kebejian L, Ruth LJ, et al. Meta-analysis of the efficacy and safety of prazosin versus placebo for the treatment of nightmares and sleep disturbances in adults with posttraumatic stress disorder. J Trauma Dissociation. 2016;17(4):494–510. - PubMed
    1. Raskind MA, Peterson K, Williams T, et al. A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan. Am J Psychiatry. 2013;170(9):1003–1010. - PubMed
    1. Raskind MA, Peskind ER, Chow B, et al. Trial of prazosin for post-traumatic stress disorder in military veterans. N Engl J Med. 2018;378(6):507–517. - PubMed
    1. McCall W, Pillai A, Case D, et al. A pilot, randomized clinical trial of bedtime doses of prazosin versus placebo in suicidal posttraumatic stress disorder patients with nightmares. J Clin Psychopharmacol. 2018;38(6):618–621. - PubMed

MeSH terms

Substances