Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;32(11):e1908109.
doi: 10.1002/adma.201908109. Epub 2020 Feb 5.

Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy

Yan Cheng  1 , Xiangpeng Kong  2 , Yun Chang  1 , Yanlin Feng  1   3 , Runxiao Zheng  1   3 , Xiaqing Wu  1   3 , Keqiang Xu  1   3 , Xingfa Gao  2 , Haiyuan Zhang  1   3
Affiliations

Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy

Yan Cheng et al. Adv Mater. 2020 Mar.

Abstract

Photodynamic therapy (PDT) efficacy has been severely limited by oxygen (O2 ) deficiency in tumors and the electron-hole separation inefficiency in photosensitizers, especially the long-range diffusion of O2 toward photosensitizers during the PDT process. Herein, novel bismuth sulfide (Bi2 S3 )@bismuth (Bi) Z-scheme heterostructured nanorods (NRs) are designed to realize the spatiotemporally synchronous O2 self-supply and production of reactive oxygen species for hypoxic tumor therapy. Both narrow-bandgap Bi2 S3 and Bi components can be excited by a near-infrared laser to generate abundant electrons and holes. The Z-scheme heterostructure endows Bi2 S3 @Bi NRs with an efficient electron-hole separation ability and potent redox potentials, where the hole on the valence band of Bi2 S3 can react with water to supply O2 for the electron on the conduction band of Bi to produce reactive oxygen species. The Bi2 S3 @Bi NRs overcome the major obstacles of conventional photosensitizers during the PDT process and exhibit a promising phototherapeutic effect, supplying a new strategy for hypoxic tumor elimination.

Keywords: Z-scheme heterostructures; hypoxic tumors; oxygen self-supply; photodynamic therapy; reactive oxygen species.

PubMed Disclaimer

References

    1. a) J. Li, J. Rao, K. Pu, Biomaterials 2018, 155, 217;
    1. b) U. Chitgupi, Y. Qin, J. F. Lovell, Nanotheranostics 2017, 1, 38.
    1. a) B. W. Henderson, V. H. Fingar, Cancer Res. 1987, 47, 3110;
    1. b) M. I. Koukourakis, A. Giatromanolaki, J. Skarlatos, L. Corti, S. Blandamura, M. Piazza, K. C. Gatter, A. L. Harris, Cancer Res. 2001, 61, 1830.
    1. H. Xiang, Y. Chen, Small 2019, 15, 1805339.

LinkOut - more resources