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Editorial
. 2020 Feb 5;12(3):2022-2023.
doi: 10.18632/aging.102829. Epub 2020 Feb 5.

Lessons for aging from Werner syndrome epigenetics

George M Martin  1 , Martin Poot  2 , Thomas Haaf  2
Affiliations
Editorial

Lessons for aging from Werner syndrome epigenetics

George M Martin et al. Aging (Albany NY). .
No abstract available

Keywords: Werner syndrome; developmental origins; epigenetic changes; premature aging; transcriptional disease.

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Figures

Figure 1
Figure 1
Developmental origins of premature and normal aging. Individuals with WRN are endowed with specific epigenetic changes in several hundred genes (indicated by red dots) before the disease manifests. This is consistent with a multifactorial model of aging, in which the WRN-specific epigenetic burden, one that may arise early in development, is associated with a lowered threshold and increased risk for age-related diseases. In order to be affected, the number of adverse factors including epigenetic changes (red dots) in an individual must exceed a certain threshold.
See this image and copyright information in PMC

Comment on

References

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