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Comment
. 2020 Feb;10(2):179-181.
doi: 10.1158/2159-8290.CD-19-1349.

Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy

Johannes Menzel  1 , Joshua C Black  2
Affiliations
Comment

Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy

Johannes Menzel et al. Cancer Discov. 2020 Feb.

Abstract

Response rates to immune checkpoint blockade (ICB) in KRAS-mutant lung adenocarcinoma remain poor. In this issue of Cancer Discovery, Li and colleagues report an in vivo CRISPR screen of epigenetic regulators of the tumor immune microenvironment that uncovers Asf1a as a tumor-intrinsic suppressor of ICB through suppression of GM-CSF expression.See related article by Li et al., p. 270.

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References

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