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Observational Study
. 2020 Feb 5;10(1):1924.
doi: 10.1038/s41598-020-58633-z.

Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study

Chao Qiang Jiang  1 , Lin Xu  2   3 , Wei Sen Zhang  1 , Ya Li Jin  1 , Feng Zhu  1 , Kar Keung Cheng  4 , Tai Hing Lam  1   5
Affiliations
Observational Study

Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study

Chao Qiang Jiang et al. Sci Rep. .

Abstract

Previous studies on Chinese showed mixed results describing the relationship between obesity and mortality. The optimum levels of body mass index (BMI) and waist circumference (WC) are inconsistent. In the Guangzhou Biobank Cohort Study, after excluding ever smokers and those with poor health, 19,405 Chinese (50+ years) recruited from 2003 to 2008 were followed-up until 2017. During an average follow-up of 11.5 (standard deviation = 2.3) years, 1,757 deaths were recorded. All-cause mortality showed a J-shaped association with BMI, with the lowest mortality risks at 22.5 kg/m2 for both men and women. In those with BMI ≥ 22.5 kg/m2, an increase of 5 kg/m2 was associated with 29% higher all-cause mortality (hazard ratio (HR) = 1.29, 95% confidence interval (CI) 1.15-1.46), 30% higher cancer mortality (1.30, 95% CI 1.08-1.57), and 37% higher cardiovascular disease (CVD) mortality (1.37, 95% CI 1.13-1.67) after adjustment for potential confounders. In this first cohort study in one of the most economically developed cities in China, the lowest all-cause mortality was observed for a BMI of 22.5 kg/m2 in all participants, and a WC of 78 cm in men and 72 cm in women.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Association of body mass index (BMI) and waist circumference with all-cause mortality in 19,405 participants of the Guangzhou Biobank Cohort Study recruited during 2003–8 and followed up till December 2017, after excluding ever smokers and those with poor health status. All hazard ratios were adjusted for age, sex, occupation, personal income, physical activity, alcohol use and self-rated health.
See this image and copyright information in PMC

References

    1. Global Health Observatory (GHO) data. http://www.who.int/gho/ncd/risk_factors/obesity_text/en/ [Access on August 2nd, 2016]. (2016).
    1. Xu Lin, Lam Tai Hing. Stage of obesity epidemic model: Learning from tobacco control and advocacy for a framework convention on obesity control. Journal of Diabetes. 2018;10(7):564–571. doi: 10.1111/1753-0407.12647. - DOI - PubMed
    1. Xu L, et al. Changes in adiposity in an older Chinese population in rapid economic transition. Obes. 2016;24:2217–2223. doi: 10.1002/oby.21599. - DOI - PubMed
    1. Ng M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766–781. doi: 10.1016/S0140-6736(14)60460-8. - DOI - PMC - PubMed
    1. Chen Z, et al. Body mass index and mortality in China: a 15-year prospective study of 220 000 men. Int. J. Epidemiol. 2012;41:472–481. doi: 10.1093/ije/dyr208. - DOI - PubMed

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