Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug;20(8):483-497.
doi: 10.1038/s41577-019-0271-z. Epub 2020 Feb 5.

Immune crosstalk in cancer progression and metastatic spread: a complex conversation

Hannah Garner  1 , Karin E de Visser  2   3
Affiliations
Review

Immune crosstalk in cancer progression and metastatic spread: a complex conversation

Hannah Garner et al. Nat Rev Immunol. 2020 Aug.

Abstract

Metastatic disease is responsible for approximately 90% of cancer deaths. For successful dissemination and metastasis, cancer cells must evade detection and destruction by the immune system. This process is enabled by factors secreted by the primary tumour that shape both the intratumoural microenvironment and the systemic immune landscape. Here, we review the evidence of aberrant immune cell crosstalk in metastasis formation and the role that primary tumours play in hijacking these interactions in order to enhance their metastatic potential. Moreover, we highlight the intriguing parallels between the inflammatory pathways underlying inflammatory disorders and cancer progression.

PubMed Disclaimer

References

    1. Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860–867 (2002). - PubMed - PMC - DOI
    1. Virchow, R. An address on the value of pathological experiments. Br. Med. J. 2, 198–203 (1881). - PubMed - PMC - DOI
    1. Ehrlich, P. Über den jetzigen stand der karzinomforschung. Nederlandsch Tijdschr. voor Geneeskunde 5, 273–290 (1909).
    1. Coley, W. B. The treatment of malignant tumors by repeated inoculations of erysipelas: with a report of ten original cases. 1. Am. J. Med. Sci. 105, 487–511 (1893). - DOI
    1. Dvorak, H. F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650–1659 (1986). This study makes the observation that tumours share many histopathological features with chronically inflamed tissue. - PubMed - DOI

Publication types

Substances

LinkOut - more resources