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Observational Study
. 2020 Jan 16:2020:8571062.
doi: 10.1155/2020/8571062. eCollection 2020.

Oscillometrically Measured Aortic Pulse Wave Velocity Reveals Asymptomatic Carotid Atherosclerosis in a Middle-Aged, Apparently Healthy Population

Renáta Marietta Böcskei  1   2 , Béla Benczúr  3 , Veronika Müller  2 , András Bikov  2 , Andrea Székely  4 , Thomas Kahan  5 , Zsófia Lenkey  1 , Róbert Husznai  1 , Attila Cziráki  1 , Miklós Illyés  1
Affiliations
Observational Study

Oscillometrically Measured Aortic Pulse Wave Velocity Reveals Asymptomatic Carotid Atherosclerosis in a Middle-Aged, Apparently Healthy Population

Renáta Marietta Böcskei et al. Biomed Res Int. .

Abstract

Background: Asymptomatic atherosclerosis is a common entity even at young age. Studies have suggested a strong relationship between increased arterial stiffness and asymptomatic carotid atherosclerosis (ACA) in general population, particularly in those with high cardiovascular risk, but no data exist from a younger population free from recognized cardiovascular disease. Hypothesis. We hypothesized there is an association between ACA and aortic pulse wave velocity (PWVao) in middle-aged, apparently healthy, normotensive population to reveal increased cardiovascular risk.

Methods: We examined the relationship between ACA and PWVao in 236 apparently healthy, asymptomatic, normotensive, middle-aged subjects (age 47 ± 8 years; 52% women). PWVao was measured with the oscillometric method (Arteriograph). ACA was assessed by carotid artery ultrasonography.

Results: ACA was present in 51 subjects. Subjects with ACA were older (p < 0.009), more likely to be smokers (p < 0.009), more likely to be smokers (p < 0.009), more likely to be smokers (p < 0.009), more likely to be smokers (p < 0.009), more likely to be smokers (p < 0.009), more likely to be smokers (p < 0.009), more likely to be smokers (p < 0.009), more likely to be smokers (.

Conclusions: PWVao measured by the Arteriograph proved to be an independent marker of ACA. Our study may reveal high CV risk, detected as increased PWVao, which according to our study is related in a very high probability to asymptomatic carotid atherosclerosis in apparently healthy, young, and middle-aged subjects.

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Conflict of interest statement

Miklós Illyés is a patent owner of the Arteriograph method and has shares in TensioMed Ltd., a company that manufactures the Arteriograph device for measuring arterial stiffness. The other authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of the number and selection of individuals in the study population.
Figure 2
Figure 2
Receiver operating characteristic curve determining asymptomatic carotid atherosclerosis by measuring aortic pulse wave analysis.
See this image and copyright information in PMC

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