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. 2019 Nov 2;5(1):70.
doi: 10.1186/s40981-019-0292-4.

Incidence of postoperative nausea and vomiting is not increased by combination of low concentration sevoflurane and propofol compared with propofol alone in patients undergoing laparoscopic gynecological surgery

Yuka Uchinami  1 , Satoshi Takikawa  2 , Fumiki Takashima  2 , Yosuke Maeda  2 , Satoki Nasu  2 , Ayumi Ito  2 , Tatushi Saito  2
Affiliations

Incidence of postoperative nausea and vomiting is not increased by combination of low concentration sevoflurane and propofol compared with propofol alone in patients undergoing laparoscopic gynecological surgery

Yuka Uchinami et al. JA Clin Rep. .

Abstract

Background: The incidence of postoperative nausea and vomiting (PONV) is higher in patients receiving volatile anesthetics than those receiving total intravenous anesthesia (TIVA) with propofol. However, it is unclear whether its incidence is increased when a low concentration of sevoflurane is used in combination with propofol.

Methods: This prospective, randomized, controlled trial enrolled women undergoing laparoscopic gynecological surgery. Patients were randomly assigned to receive general anesthesia either with propofol alone (group P) or with 0.8% sevoflurane and propofol (group SP, n = 36, each group) for maintenance of anesthesia. The incidence of PONV and the number of patients who required antiemetics were compared.

Results: There were no differences in the incidence of PONV and the number of patients who required antiemetics between the P and SP groups.

Conclusions: A combination of 0.8% sevoflurane and propofol to maintain anesthesia does not increase the incidence of PONV compared with TIVA with propofol.

Trial registration: UMIN-CTR UMIN000023647 , registered 14 August 2016.

Keywords: Postoperative nausea and vomiting; Propofol; Sevoflurane; Sevoflurane propofol combination.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of patients enrolled in the study
Fig. 2
Fig. 2
Incidence of postoperative nausea and vomiting. Anesthesia was maintained with propofol (group P) and with a combination of sevoflurane and propofol (group SP)
See this image and copyright information in PMC

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